Microstructural analysis of skeletal muscle force generation during aging.
Microstructural analysis of skeletal muscle force generation during aging.
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DOI：
10.1002/cnm.3295
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发表时间：
2020-01
影响因子：
2.1
通讯作者：
Sinha S
中科院分区：
文献类型：
--
作者：
Zhang Y;Chen JS;He Q;He X;Basava RR;Hodgson J;Sinha U;Sinha S
人体衰老导致骨骼肌主动发力能力的逐渐下降。虽然与肌纤维和细胞外基质（ECM）的形态和结构特性变化有关的许多因素被认为是导致年龄相关的力减少的可能原因，但仍然没有完全理解为什么偏心收缩（延长）时力产生的减少远小于同心收缩（缩短）。生物力学上，结缔组织（肌内膜）随着年龄的增长而变硬，结缔组织的体积比呈现出与年龄相关的增加。然而，有限的骨骼肌模型考虑了组织材料的微观结构特征和体积分数。本研究旨在提供一项数值研究，其中肌肉纤维和ECM明确表示，以便定量评估与年龄相关的力减少机制。为此，通过基于像素的再现核粒子方法（RKPM）构建和建模了纤维级蜂窝状微观结构，该方法允许在材料界面上对生物材料特性的平滑过渡进行建模。数值研究表明，肌肉组织被动材料刚度的增加降低了同心收缩时的发力能力，而保持了偏心收缩时的发力能力。提出的RKPM微观模型为骨骼肌生理的细胞尺度数值研究提供了有效的手段。
Human aging results in a progressive decline in the active force generation capability of skeletal muscle. While many factors related to the changes of morphological and structural properties in muscle fibers and the extracellular matrix (ECM) have been considered as possible reasons for causing age-related force reduction, it is still not fully understood why the decrease in force generation under eccentric contraction (lengthening) is much less than that under concentric contraction (shortening). Biomechanically, it was observed that connective tissues (endomysium) stiffen as ages, and the volume ratio of connective tissues exhibits an age-related increase. However, limited skeletal muscle models take into account the microstructural characteristics as well as the volume fraction of tissue material. This study aims to provide a numerical investigation in which the muscle fibers and the ECM are explicitly represented to allow quantitative assessment of the age-related force reduction mechanism. To this end, a fiber-level honeycomb-like microstructure is constructed and modeled by a pixel-based Reproducing Kernel Particle Method (RKPM), which allows modeling of smooth transition in biomaterial properties across material interfaces. The numerical investigation reveals that the increased stiffness of the passive materials of muscle tissue reduces the force generation capability under concentric contraction while maintains the force generation capability under eccentric contraction. The proposed RKPM microscopic model provides effective means for the cellular-scale numerical investigation of skeletal muscle physiology.
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基于像素基的骨骼肌的无网格建模。
DOI：
10.1080/21681163.2015.1049712
发表时间：
2016
期刊：
Computer methods in biomechanics and biomedical engineering. Imaging & visualization
影响因子：
--
作者：
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Sinha S
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10.1080/10255840701771750
发表时间：
2008-01-01
影响因子：
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