Radioimmunotherapy Is More Effective than Antifungal Treatment in Experimental Cryptococcal Infection
Radioimmunotherapy Is More Effective than Antifungal Treatment in Experimental Cryptococcal Infection
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DOI：
10.1086/654813
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发表时间：
2010-08-15
影响因子：
6.4
通讯作者：
Dadachova, Ekaterina
中科院分区：
文献类型：
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作者：
Bryan, Ruth A.;Jiang, Zewei;Dadachova, Ekaterina
放射免疫疗法（RIT）可延长感染新型隐球菌的小鼠的存活时间。为了比较 RIT 与两性霉素 B 的功效，我们用非黑化或黑化新型隐球菌细胞静脉注射感染 AJ/Cr 小鼠。受感染的小鼠要么不治疗，要么在感染 Bi-213-18B7 抗体、两性霉素 B 或两者后 24 小时进行治疗。感染前的黑化并没有增加新生隐球菌体内对RIT的抵抗力。 Bi-213-18B7治疗几乎完全消除了肺和脑中的集落形成单位，而两性霉素B并没有减少集落形成单位的数量。我们得出的结论是，RIT 比两性霉素 B 对新型隐球菌全身感染更有效。
Radioimmunotherapy (RIT) prolongs the survival of mice infected with Cryptococcus neoformans. To compare the efficacy of RIT with that of amphotericin B, we infected AJ/Cr mice intravenously with either nonmelanized or melanized C. neoformans cells. Infected mice were either left untreated or treated 24 h after infection with Bi-213-18B7 antibody, amphotericin B, or both. Melanization before infection did not increase resistance of C. neoformans to RIT in vivo. Bi-213-18B7 treatment almost completely eliminated colony-forming units from the lung and brain, whereas amphotericin B did not decrease the number of colony-forming units. We conclude that RIT is more effective than amphotericin B against systemic infection with C. neoformans.