Comparison of ventilatory support with intratracheal perfluorocarbon administration and conventional mechanical ventilation in animals with acute respiratory failure.
Comparison of ventilatory support with intratracheal perfluorocarbon administration and conventional mechanical ventilation in animals with acute respiratory failure.
复制标题
急性呼吸衰竭动物气管内全氟化碳给药和常规机械通气的通气支持比较。
DOI：
10.1164/ajrccm/148.3.785
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发表时间：
1993
期刊：
影响因子：
--
通讯作者：
B. Lachmann
中科院分区：
文献类型：
--
作者：
A. Tütüncü;N. Faithfull;B. Lachmann
我们研究了气管内给予全氟化碳(PFC)联合机械通气支持急性呼吸衰竭成年动物气体交换的效果。在呼吸参数和死后肺组织学方面，这些与接受持续正压通气(CPPV)治疗的类似组的动物进行了比较。成年兔18只，生理盐水肺灌洗后，随机分为3组，每组6只。所有组均接受常规CPPV治疗。另外，一组气管内注入18ml/kg的PFC(相当于功能残存容量)(PFC组)，另一组给予18ml/kg的生理盐水(生理盐水组)，最后一组不作进一步治疗(CPPV组)。各组均采用100%氧气，相同的呼吸机设置为潮气量12ml/kg，呼吸频率30次/min，呼气末正压6cmH2O。PFC组PaO2从67.2+/-11.4 mm Hg升至424.2+/-14 mm Hg，并维持稳定3h，PaCO2值保存良好。只有PFC组的呼吸道压力显著降低，呼吸系统顺应性增加。CPPV组PaO2维持在60 mm Hg左右，PaCO2逐渐升高。在急性呼吸衰竭时采用常规机械通气的PFC治疗被证明是一种成功的支持技术，可以在低充气压力下改善气体交换。
We investigated the efficacy of intratracheal perfluorocarbon (PFC) administration combined with mechanical ventilation to support gas exchange in adult animals with acute respiratory failure. These were compared with a similar group of animals treated with continuous positive-pressure ventilation (CPPV) with respect to respiratory parameters and postmortem lung histology. After lung lavage with saline, 18 adult rabbits were divided into three groups (n = 6 per group). All groups received conventional CPPV. Additionally, one group received intratracheal PFC administration at a volume of 18 ml/kg (corresponding to functional residual capacity) (PFC group); another received 18 ml/kg of saline administration (saline group), and the last had no further treatment (CPPV group). All groups were ventilated for 3 h using 100% oxygen, with the same ventilator settings of tidal volume of 12 ml/kg, respiratory frequency of 30/min, and positive end-expiratory pressure of 6 cm H2O. In the PFC group, PaO2 increased from 67.2 +/- 11.4 to 424.2 +/- 14 mm Hg and remained stable for 3 h with well-preserved PaCO2 values. Only in the PFC group were significant decreases in airway pressures and increase in respiratory system compliance seen. In the CPPV group, PaO2 stayed around 60 mm Hg and PaCO2 gradually increased. PFC treatment with conventional mechanical ventilation in acute respiratory failure proved to be a successful supportive technique to improve gas exchange at low inflation pressures.