Galectin-1 and galectin-3 expression in human prostate tissue and prostate cancer
Galectin-1 and galectin-3 expression in human prostate tissue and prostate cancer
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DOI：
10.1007/s002400050164
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发表时间：
1999-10-01
影响因子：
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通讯作者：
Lotan, R
中科院分区：
文献类型：
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作者：
Ellerhorst, J;Troncoso, P;Lotan, R
半乳糖凝集素-1和半乳糖凝集素-3是两种β-半乳糖苷结合蛋白，已被认为在癌症的发生和发展中起作用。我们研究了这些分子在正常人前列腺组织和前列腺腺癌中的表达。免疫组织化学被用来检查福尔马林固定，石蜡包埋切片的7个正常人前列腺，8例前列腺上皮内瘤变（PIN），20个原发性腺癌的前列腺，和12个前列腺癌转移。Galectin-1在所有四种组织学类型的大多数病例中表达。与此相反，galectin-3的表达显着降低，在原发性癌和转移性疾病相比，正常和癌前组织。Galectin-3在原发肿瘤中的表达倾向于低于周围正常腺体。我们的结论是，半乳糖凝集素-3表达的损失可能与前列腺癌的进展。
Galectin-1 and galectin-3, two beta-galactoside-binding proteins, have been suggested to play a role in the development and progression of cancer. We have studied the expression of these molecules in normal human prostate tissue and prostate adenocarcinoma. Immunohistochemistry was used to examine formalin-fixed, paraffin-embedded sections of seven normal human prostates, eight cases of prostatic intraepithelial neoplasia (PIN), 20 primary adenocarcinomas of the prostate, and 12 prostate cancer metastases. Galectin-1 was expressed in most cases of all four histologic types. In contrast, galectin-3 expression was significantly decreased in primary carcinoma and metastatic disease compared with normal and premalignant tissue. Galectin-3 expression in primary tumors tended to be less than that of surrounding normal glands. We conclude that loss of galectin-3 expression may be associated with the progression of prostate cancer.