Reduction and esterification of cholesterol and sitosterol by homogenates of feces.
Reduction and esterification of cholesterol and sitosterol by homogenates of feces.
复制标题
DOI：
--
复制
发表时间：
1971-03
影响因子：
6.5
通讯作者：
R. Rosenfeld;L. Hellman
中科院分区：
文献类型：
--
作者：
R. Rosenfeld;L. Hellman
胆固醇-1，2-（3）H和谷甾醇-4-（14）C的混合物与粪便悬浮液一起孵育，以比较植物甾醇的行为与已知在这些条件下胆固醇发生的转化。在研究的限制范围内，两种标记的甾醇被酯化至相同的程度，并且在两种物质中相同地进行Delta（5）双键至饱和类似物的还原。校正程序损失后，孵育物中（3）H和（14）C的回收率始终低于对照;这强烈表明粪便微生物对甾醇的破坏。
Mixtures of cholesterol-1,2-(3)H and sitosterol-4-(14)C have been incubated with suspensions of feces in order to compare the behavior of the phytosterol with transformations known to take place with cholesterol under these conditions. Within the limitations of the study, both labeled sterols were esterified to the same extent, and reduction of the Delta(5) double bond to the saturated analogue proceeded equally in both substances. After correcting for procedural losses, the recoveries of (3)H and (14)C from the incubations were always less than the controls; this strongly indicates destruction of sterol by feces microorganisms.