CHRONIC DISEASE SURVEILLANCE AND TESTING OF CLUSTERING OF DISEASE AND EXPOSURE - APPLICATION TO LEUKEMIA INCIDENCE AND TCE-CONTAMINATED DUMPSITES IN UPSTATE NEW-YORK
CHRONIC DISEASE SURVEILLANCE AND TESTING OF CLUSTERING OF DISEASE AND EXPOSURE - APPLICATION TO LEUKEMIA INCIDENCE AND TCE-CONTAMINATED DUMPSITES IN UPSTATE NEW-YORK
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DOI：
10.1002/env.3170030303
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发表时间：
1992-09-01
期刊：
影响因子：
1.7
通讯作者：
NASCA, P
中科院分区：
文献类型：
--
作者：
WALLER, LA;TURNBULL, BW;NASCA, P
统计学家和流行病学家对大地理区域的不良健康事件，特别是癌症的“聚集性”监测很感兴趣。最近的统计研究涉及所谓的“集中”疾病聚集，即在预先规定的、假定的风险增加的焦点附近聚集疾病病例。我们介绍了具有最优或接近最优功率特性的集中聚类的统计测试。本文利用纽约州北部地区1978-1982年白血病发病率数据说明并比较了这一试验和最近另外两项集中聚类试验，其中含有三氯乙烯的非活性危险废物场址是疑似疫源地。一旦确定了潜在的问题区域，就可以应用更局部化的方法。
Surveillance of large geographic areas for ''clusters'' of adverse health events, particularly cancers, has interested statisticians and epidemiologists. Recent statistical research involves so-called ''focused'' clustering of disease, i.e. aggregation of incident cases of disease in the vicinity of prespecified, putative foci of increased risk. We introduce a statistical test of focused clustering with optimal, or near-optimal power properties. This test, and two other recent tests of focused clustering are illustrated and compared using leukemia incidence data for 1978-1982 in a region of upstate New York, with inactive hazardous waste sites containing trichloroethylene acting as the suspected foci. Once potential problem areas are identified, more localized methods may be applied.