The organization, structure, and inheritance of the ER in higher and lower eukaryotes
The organization, structure, and inheritance of the ER in higher and lower eukaryotes
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DOI：
10.1139/o05-159
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发表时间：
2005-12-01
影响因子：
2.9
通讯作者：
Ferro-Novick, S
中科院分区：
文献类型：
--
作者：
de Martin, PE;Novick, P;Ferro-Novick, S
内质网 (ER) 是蛋白质组装、脂质生物合成和囊泡运输所需的基本细胞器 (McMaster 2001; Staehelin 1997; Voeltz et al. 2002)，以及钙储存和钙从 ER 腔到细胞质中的受控释放 (Johnson 和 van Waes 1999; Ma 和 Hendershot 2002; Matlack 等)等，1998；梅尔多莱西和波赞，1998）。通过囊泡介导的运输与内质网功能性连接的膜，如高尔基复合体、内体、液泡-溶酶体、分泌囊泡和质膜，主要源自内质网中合成的蛋白质和脂质（Voeltz et al. 2002）。在这篇综述中，我们将讨论 ER 的结构组织及其继承。
The endoplasmic reticulum (ER) is a fundamental organelle required for protein assembly, lipid biosynthesis, and vesicular traffic (McMaster 2001; Staehelin 1997; Voeltz et al. 2002), as well as calcium storage and the controlled release of calcium from the ER lumen into the cytosol (Johnson and van Waes 1999; Ma and Hendershot 2002; Matlack et al. 1998; Meldolesi and Pozzan 1998). Membranes functionally linked to the ER by vesicle-mediated transport, such as the Golgi complex, endosomes, vacuoles-lysosomes, secretory vesicles, and the plasma membrane, originate largely from proteins and lipids synthesized in the ER (Voeltz et al. 2002). In this review we will discuss the structural organization of the ER and its inheritance.