CORONARY OSCILLATORY FLOW AMPLITUDE IS MORE AFFECTED BY PERFUSION-PRESSURE THAN VENTRICULAR PRESSURE
CORONARY OSCILLATORY FLOW AMPLITUDE IS MORE AFFECTED BY PERFUSION-PRESSURE THAN VENTRICULAR PRESSURE
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DOI：
10.1152/ajpheart.1990.258.6.h1889
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发表时间：
1990-06-01
影响因子：
--
通讯作者：
WESTERHOF, N
中科院分区：
文献类型：
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作者：
KRAMS, R;SIPKEMA, P;WESTERHOF, N
本文研究了在不同恒定灌流压(PP)水平下，左心室发展压(DeltaPiv)与冠脉振荡血流幅度(舒张期与收缩期流量之差，DeltaF)的关系。我们假设，心肌收缩对相流的影响是由于心肌弹性性质的变化所致。冠状动脉室和左室腔室一样，可以用时变弹性来描述。这一概念预测，左心室压力对增量F的影响很小，而PP的影响是相当大的。瀑布模型和心肌内泵模型都预测相反的情况。当PP为10kPa时，deltaPiv与deltaF的关系为deltaF=(4.71+/-3.08)，deltaPiv+337+/-75(斜率单位为mL.min-1.100 g-1.kpa-1，截距单位为mL.min-1.100 g-1；n=7)；在常数为10kPa时，PP与增量F之间的关系为：增量F=51.Pp+211(斜率单位为mL.min-1.100 g-1.kpa-1，截距单位为mL.min-1.100 g-1；n=6)。用时变弹性概念最好地预测了坡度的差异。
In this study on the isolated, maximally vasodilated, blood-perfused cat heart we investigated the relation between left ventricular developed pressure (delta Piv) and coronary oscillatory flow amplitude (diastolic minus systolic flow, delta F) at different levels of constant perfusion pressure (Pp). We hypothesized that the effect of cardiac contraction on the phasic flow results from the changing elastic properties of cardiac muscle. The coronary vessel compartment can, as can the left ventricular lumen compartment, be described by a time-varying elastance. This concept predicts that the effect of left ventricular pressure on delta F is small, whereas the effect of Pp is considerable. Both the waterfall model and the intramyocardial pump model predict the inverse. The relation between delta Piv and delta F at a Pp of 10 kPa is delta F = (4.71 +/- 3.08).delta Piv + 337 +/- 75 (slope in ml.min-1.100 g-1.kPa-1 and intercept in ml.min-1.100 g-1; n = 7); the relation between (constant levels of) Pp and delta F at a constant delta Piv of 10 kPa is delta F = 51.Pp + 211 (slope in ml.min-1.100 g-1.kPa-1 and intercept in ml.min-1.100 g-1; n = 6). The differences in slope are best predicted by the time-varying elastance concept.