Electroacupuncture effects in a rat model of complete Freund's adjuvant-induced inflammatory pain: Antinociceptive effects enhanced and tolerance development accelerated
Electroacupuncture effects in a rat model of complete Freund's adjuvant-induced inflammatory pain: Antinociceptive effects enhanced and tolerance development accelerated
复制标题
电针对完全弗氏佐剂引起的炎症性疼痛大鼠模型的影响：镇痛作用增强，耐受性发展加速
DOI：
10.1007/s11064-008-9721-x
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发表时间：
2008-10-01
影响因子：
4.4
通讯作者：
Wan, You
中科院分区：
文献类型：
--
作者：
Huang, Cheng;Huang, Zhi-Qin;Wan, You
我们先前已经证明，在急性伤害性感受过程中，电针(EA)通过释放内源性阿片肽来激活阿片受体而产生抗伤害效应。EA在长期使用后产生了耐受性。有报道称，100 Hz电针可减轻完全弗氏佐剂(CFA)诱导的炎性伤害性痛大鼠的机械性痛敏反应。本研究旨在探讨电针对慢性炎症性伤害性痛大鼠的抗伤害性作用及其对电针耐受性的影响。结果表明，100 Hz电针能显著增强CFA诱导的炎性伤害性痛大鼠的抗伤害性作用。纳洛酮20 mg/kg可显著阻断这种抗伤害性作用。与正常大鼠相比，CFA诱导的炎性伤害性大鼠对电针的慢性耐受形成得更快。因此，100 Hz电针可增强CFA诱导的炎性伤害性痛大鼠的抗伤害性作用，促进其耐受性的形成。电针增强CFA炎性伤害性痛大鼠的抗伤害性作用可能与强啡肽等内源性阿片肽有关。
We have previously shown that electroacupuncture (EA) produced antinociception through the release of endogenous opioid peptides to activate opioid receptors during acute nociception. EA produced tolerance after its prolonged application. It has reported that 100 Hz EA could reduce mechanical hyperalgesia in complete Freund's adjuvant (CFA)-induced inflammatory nociception rats. The present study aims to investigate the antinociceptive effect of EA and the development of EA tolerance in chronic inflammatory nociception rats with CFA injection into the hind paw plantar. The results showed that the antinociceptive effect of 100 Hz EA was significantly enhanced in CFA-induced inflammatory nociception rats. Naloxone at 20 mg/kg could significantly block this antinociceptive effect. Chronic tolerance to EA was developed faster in CFA-induced inflammatory nociception rats than in normal rats. Therefore, 100 Hz EA could enhance antinociceptive effects and accelerate tolerance development in CFA-induced inflammatory nociception rats. The enhancement of EA antinociceptive effect in CFA-induced inflammatory nociception rats might involve the endogenous opioid peptides such as dynorphin.