Epidemiology and Diagnostics of Carbapenem Resistance in Gram-negative Bacteria
Epidemiology and Diagnostics of Carbapenem Resistance in Gram-negative Bacteria
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DOI：
10.1093/cid/ciz824
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发表时间：
2019-12-01
影响因子：
11.8
通讯作者：
Poirel, Laurent
中科院分区：
文献类型：
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作者：
Nordmann, Patrice;Poirel, Laurent
革兰氏阴性菌对碳青霉烯类抗生素的耐药性已经导致了一种持续增长的全球流行病。尽管产碳青霉烯酶肠杆菌科最受关注，因为在20世纪90年代初首次报告了这些病原体的耐药性，但人们越来越认识到碳青霉烯耐药非发酵革兰氏阴性菌的影响，如鲍曼不动杆菌、铜绿假单胞菌和嗜麦芽窄食单胞菌。此外，评估碳青霉烯耐药问题需要考虑产碳青霉烯酶细菌以及具有其他碳青霉烯耐药机制的细菌。快速诊断测试的进步，以改善碳青霉烯耐药性的检测和使用大型，基于人群的数据集，以捕获更大比例的碳青霉烯耐药微生物，可以帮助我们更好地了解这一紧迫的威胁，使医生能够选择最合适的抗生素。
Carbapenem resistance in gram-negative bacteria has caused a global epidemic that continues to grow. Although carbapenemase-producing Enterobacteriaceae have received the most attention because resistance was first reported in these pathogens in the early 1990s, there is increased awareness of the impact of carbapenem-resistant nonfermenting gram-negative bacteria, such as Acinetobacter baumannii, Pseudomonas aeruginosa, and Stenotrophomonas maltophilia. Moreover, evaluating the problem of carbapenem resistance requires the consideration of both carbapenemase-producing bacteria as well as bacteria with other carbapenem resistance mechanisms. Advances in rapid diagnostic tests to improve the detection of carbapenem resistance and the use of large, population-based datasets to capture a greater proportion of carbapenem-resistant organisms can help us gain a better understanding of this urgent threat and enable physicians to select the most appropriate antibiotics.