Prevalence of Parkinson's disease in the elderly: The Rotterdam study
Prevalence of Parkinson's disease in the elderly: The Rotterdam study
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DOI：
10.1212/wnl.45.12.2143
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发表时间：
1995-12-01
期刊：
影响因子：
9.9
通讯作者：
Hofman, A
中科院分区：
文献类型：
--
作者：
deRijk, MC;Breteler, MMB;Hofman, A
我们评估了帕金森病（PD）在荷兰一般老年人群中的患病率。该研究是鹿特丹研究的一部分，该研究是一项基于人群的挨家挨户研究，包括居住在荷兰鹿特丹郊区的6，969名55岁或以上的人。所有参与者都接受了检查，那些在神经系统筛查中至少有一个可能的帕金森综合征的主要体征，报告他们患有PD，或正在服用抗帕金森病药物的人被邀请进行进一步评估。该人群的PD患病率为1.4%（男性为1.2%，女性为1.5%）。患病率随着年龄的增长而增加，55至64岁的患病率为0.3%，65至74岁的患病率为1.0%，75至84岁的患病率为3.1%，85至94岁的患病率为4.3%。男性的相应年龄段数字分别为0.4%、1.2%、2.7%和3.0%，女性分别为0.2%、0.8%、3.4%和4.8%。在95至99岁的妇女中，患病率为5.0%。12%的PD受试者是通过筛查发现的，以前没有被诊断过。
We assessed the prevalence of Parkinson's disease (PD) in a general elderly population in the Netherlands. The study formed part of the Rotterdam Study, a population-based door-to-door study, and included 6,969 persons 55 years of age or older living in a suburb of Rotterdam, the Netherlands. All participants were examined, and those who either had at least one possible cardinal sign of parkinsonism at the neurologic screening, reported that they had PD, or were taking antiparkinsonian drugs were invited for further evaluation. The prevalence of PD in this population was 1.4% (1.2% for men, 1.5% for women). Prevalence increased with age, and prevalence figures were 0.3% for those aged 55 to 64 years, 1.0% for those 65 to 74, 3.1% for those 75 to 84, and 4.3% for those 85 to 94. The corresponding age-specific figures for men were 0.4%, 1.2%, 2.7%, and 3.0%, and for women, 0.2%, 0.8%, 3.4%, and 4.8%. Among 95- to 99-year-old women the prevalence was 5.0%. Twelve percent of the subjects with PD were detected through the screening and had not been diagnosed previously.