Targeting the ubiquitin proteasome pathway for the treatment of septic shock in patients
Targeting the ubiquitin proteasome pathway for the treatment of septic shock in patients
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DOI：
10.1186/cc7946
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发表时间：
2009-01-01
期刊：
影响因子：
15.1
通讯作者：
Gray, Douglas A.
中科院分区：
文献类型：
--
作者：
Brun, Jan;Gray, Douglas A.
内毒素休克是对外部生物应激源的严重全身炎症反应。 NF-kappa B 的响应能力建立在涉及泛素蛋白酶体途径的快速蛋白质修饰和降解基础上。使用转基因小鼠，我们获得了体内证据，表明干扰该途径可以减轻中毒性休克的症状。我们认为给予蛋白酶体抑制剂可能会提高脓毒性休克患者的生存率。
Endotoxic shock is a serious systemic inflammatory response to an external biological stressor. The responsiveness of NF-kappa B is built upon rapid protein modification and degradation involving the ubiquitin proteasome pathway. Using transgenic mice, we have obtained in vivo evidence that interference with this pathway can alleviate the symptoms of toxic shock. We posit that administration of proteasome inhibitors may enhance the survival of patients with septic shock.