Pediatric Organ Dysfunction Information Update Mandate (PODIUM) Contemporary Organ Dysfunction Criteria: Executive Summary.
Pediatric Organ Dysfunction Information Update Mandate (PODIUM) Contemporary Organ Dysfunction Criteria: Executive Summary.
复制标题
DOI：
10.1542/peds.2021-052888b
复制
发表时间：
2022-01-01
期刊：
影响因子：
8
通讯作者：
Zimmerman, Jerry J.
中科院分区：
文献类型：
--
作者：
Bembea, Melania M.;Agus, Michael;Akcan-Arikan, Ayse;Alexander, Peta;Basu, Rajit;Bennett, Tellen D.;Bohn, Desmond;Brandao, Leonardo R.;Brown, Ann-Marie;Carcillo, Joseph A.;Checchia, Paul;Cholette, Jill;Cheifetz, Ira M.;Cornell, Timothy;Doctor, Allan;Eckerle, Michelle;Erickson, Simon;Farris, Reid W. D.;Faustino, E. Vincent S.;Fitzgerald, Julie C.;Fuhrman, Dana Y.;Giuliano, John S., Jr.;Guilliams, Kristin;Gaies, Michael;Gorga, Stephen M.;Hall, Mark;Hanson, Sheila J.;Hartman, Mary;Hassinger, Amanda B.;Irving, Sharon Y.;Jeffries, Howard;Jouvet, Philippe;Kannan, Sujatha;Karam, Oliver;Khemani, Robinder G.;Kissoon, Niranjan;Lacroix, Jacques;Laussen, Peter;Leclerc, Francis;Lee, Jan Hau;Leteurtre, Stephane;Lobner, Katie;McKiernan, Patrick J.;Menon, Kusum;Monagle, Paul;Muszynski, Jennifer A.;Odetola, Folafoluwa;Parker, Robert;Pathan, Nazima;Pierce, Richard W.;Pineda, Jose;Prince, Jose M.;Robinson, Karen A.;Rowan, Courtney M.;Ryerson, Lindsay M.;Sanchez-Pinto, L. Nelson;Schlapbach, Luregn J.;Selewski, David T.;Shekerdemian, Lara S.;Simon, Dennis;Smith, Lincoln S.;Squires, James E.;Squires, Robert H.;Sutherland, Scott M.;Ouellette, Yves;Spaeder, Michael C.;Srinivasan, Vijay;Steiner, Marie E.;Tasker, Robert C.;Thiagarajan, Ravi;Thomas, Neal;Tissieres, Pierre;Traube, Chani;Tucci, Marisa;Typpo, Katri, V;Wainwright, Mark S.;Ward, Shan L.;Watson, R. Scott;Weiss, Scott;Whitney, Jane;Willson, Doug;Wynn, James L.;Yehya, Nadir;Zimmerman, Jerry J.
Prior criteria for organ dysfunction in critically ill children were based mainly on expert opinion. We convened the Pediatric Organ Dysfunction Information Update Mandate (PODIUM) expert panel to summarize data characterizing single and multiple organ dysfunction and to derive contemporary criteria for pediatric organ dysfunction. The panel was composed of 88 members representing 47 institutions and 7 countries. We conducted systematic reviews of the literature to derive evidence-based criteria for single organ dysfunction for neurologic, cardiovascular, respiratory, gastrointestinal, acute liver, renal, hematologic, coagulation, endocrine, endothelial and immune system dysfunction. We searched the PubMed and EMBASE databases from January 1992 to January 2020. Study identification was accomplished using a combination of medical subject heading terms and text words related to concepts of pediatric organ dysfunction. Electronic searches were conducted by medical librarians. Studies were eligible for inclusion if they reported original data collected in critically ill children, evaluated performance characteristics of scoring tool(s) or clinical assessments for organ dysfunction, and assessed a patient-centered, clinically meaningful outcome. Data were abstracted from each included study into an electronic data extraction form. Risk of bias was assessed using the Quality in Prognosis Studies tool. Consensus was achieved for a final set of 43 criteria for pediatric organ dysfunction employing iterative voting and discussion. While the PODIUM criteria for organ dysfunction were limited by available evidence and will require validation, they provide a contemporary foundation for researchers to identify and study single and multiple organ dysfunction in critically ill children. We present evidence-informed, consensus criteria for organ dysfunction in critically-ill children, following systematic reviews of the literature on organ dysfunction clinical assessments and scoring tools.
Prior criteria for organ dysfunction in critically ill children were based mainly on expert opinion. We convened the Pediatric Organ Dysfunction Information Update Mandate (PODIUM) expert panel to summarize data characterizing single and multiple organ dysfunction and to derive contemporary criteria for pediatric organ dysfunction. The panel was composed of 88 members representing 47 institutions and 7 countries. We conducted systematic reviews of the literature to derive evidence-based criteria for single organ dysfunction for neurologic, cardiovascular, respiratory, gastrointestinal, acute liver, renal, hematologic, coagulation, endocrine, endothelial and immune system dysfunction. We searched the PubMed and EMBASE databases from January 1992 to January 2020. Study identification was accomplished using a combination of medical subject heading terms and text words related to concepts of pediatric organ dysfunction. Electronic searches were conducted by medical librarians. Studies were eligible for inclusion if they reported original data collected in critically ill children, evaluated performance characteristics of scoring tool(s) or clinical assessments for organ dysfunction, and assessed a patient-centered, clinically meaningful outcome. Data were abstracted from each included study into an electronic data extraction form. Risk of bias was assessed using the Quality in Prognosis Studies tool. Consensus was achieved for a final set of 43 criteria for pediatric organ dysfunction employing iterative voting and discussion. While the PODIUM criteria for organ dysfunction were limited by available evidence and will require validation, they provide a contemporary foundation for researchers to identify and study single and multiple organ dysfunction in critically ill children. We present evidence-informed, consensus criteria for organ dysfunction in critically-ill children, following systematic reviews of the literature on organ dysfunction clinical assessments and scoring tools.