Assessing the intracellular fate of rhodium(ii) complexes.

Assessing the intracellular fate of rhodium(ii) complexes.
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评估铑(ii)络合物的细胞内命运。

DOI:
10.1039/c6cc05192h
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发表时间:
2016
期刊:
Chemical communications (Cambridge, England)
影响因子:
--
通讯作者:
Ball,ZacharyT
Ball,ZacharyT
中科院分区:
--
文献类型:
--
作者:
Minus,MatthewB;Kang,MarciK;Knudsen,SarahE;Liu,Wei;Krueger,MichaelJ;Smith,MorgenL;Redell,MicheleS;Ball,ZacharyT

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Rh(II)-荧光团结合物具有很强的基于铑的荧光猝灭,可用于报告结合物的细胞摄取和细胞内分解速率。从这项研究中获得的信息使改进的STAT3金属抑制剂得以设计。
Rhodium(II)–fluorophore conjugates have strong rhodium-based fluorescence quenching that can be harnessed to report on a conjugate's cellular uptake and the intracellular decomposition rate. Information gleened from this study allowed the design of an improved STAT3 metalloinhibitor.