Long-term effect of whole-body X-irradiation on cell-mediated immune reaction in mice.
Long-term effect of whole-body X-irradiation on cell-mediated immune reaction in mice.
复制标题
全身X射线照射对小鼠细胞介导的免疫反应的长期影响。
DOI：
10.1269/jrr.30.226
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发表时间：
1989
影响因子：
2
通讯作者：
T. Tsuchiya
中科院分区：
文献类型：
--
作者：
T. Norimura;T. Tsuchiya
在全身照射后10至91周，通过测定对移植肿瘤局部照射诱导和/或增强的宿主小鼠中特异性抗肿瘤细胞介导的免疫，检查了与肿瘤相关的免疫活性变化。未照射的C_3H/He雌性小鼠的中位生存期为98.6周，而在10-12周龄时接受2和4戈伊250 kVp X射线照射的小鼠的中位生存期分别缩短了14.9和23.4周。肿瘤局部照射后2周内的肿瘤缩小率和肿瘤照射小鼠脾细胞的生长抑制活性在全身照射后10周以剂量依赖的方式降低，但在几个月内恢复到未照射对照的接近完全的水平，然后随着正常衰老而逐渐降低。这些结果表明，这种免疫活性的年龄依赖性下降出现在照射小鼠早期作为全身X射线照射在年轻的年龄，这表明加速老化的免疫系统。
Age-related change in immunological activity was examined at 10 to 91 weeks following whole-body irradiation by determining the specific anti-tumor cell-mediated immunity in host mice induced and/or enhanced by local irradiation to transplanted tumor. Median survival time of the non-irradiated C3H/He female mice was 98.6 weeks while the median life-span of the mice exposed to two and four Gy of 250kVp X-rays at the age of 10-12 weeks was shortened by 14.9 and 23.4 weeks, respectively. The rate of tumor reduction within two weeks after local irradiation to tumor and the growth inhibitory activity of spleen cells from tumor irradiated mice were reduced in a dose-dependent manner when assessed 10 weeks after whole-body irradiation, but recovered to the near-complete level of the non-irradiated controls within a few months, then gradually decreased with normal aging. These results suggest that the age-dependent decline of this immunological activity appears earlier in the irradiated mice as a result of whole-body X-irradiation at a young age, suggesting accelerated aging of the immune system.