Nicotine-like discriminative stimulus effects of bupropion in rats.
Nicotine-like discriminative stimulus effects of bupropion in rats.
复制标题
安非他酮对大鼠的尼古丁样辨别刺激作用。
DOI：
--
复制
发表时间：
2002
影响因子：
2.3
通讯作者：
M. Damaj
中科院分区：
文献类型：
--
作者：
J. Wiley;Kari L. Lavecchia;B. Martin;M. Damaj
Bupropion, a tobacco-cessation product, shares discriminative stimulus effects with cocaine and methamphetamine. The discriminative stimulus effects of these drugs, in turn, overlap with those of nicotine. This study investigated the overlap in discriminative stimulus effects of bupropion and nicotine. Rats were trained to discriminate 0.4 mg/kg (-)-nicotine from saline in 2-lever drug discrimination. Both nicotine and bupropion substituted for nicotine; however, nicotine's effects were blocked by the nicotinic antagonist mecamylamine, whereas those of bupropion were not. These results suggest that bupropion may be producing its nicotine-like discriminative stimulus effects through a different mechanism than nicotine. Given bupropion's shared pharmacology with dopamine transport inhibitors, these effects may be produced in part through bupropion's actions on dopaminergic neurotransmission.
登录
查看更多内容
尼古丁作为区别刺激：研究中枢胆碱能机制的神经生物行为方法。
DOI：
--
发表时间：
1989
期刊：
Journal of substance abuse
影响因子：
--
作者：
Rosecrans,JA
通讯作者：
Rosecrans,JA
DOI：
--
发表时间：
1989-10
期刊：
The Journal of pharmacology and experimental therapeutics
影响因子：
--
作者：
J. Bergman;B. Madras;S. E. Johnson;R. Spealman
通讯作者：
J. Bergman;B. Madras;S. E. Johnson;R. Spealman
通过人体转运蛋白释放多巴胺。
影响因子：
3.6
作者：
Eshleman,AJ;Henningsen,RA;Neve,KA;Janowsky,A
通讯作者：
Janowsky,A
苯环己哌啶的反应率和辨别刺激效果的分离：训练剂量作为苯环己哌啶-盐水辨别的一个因素。
DOI：
--
发表时间：
1987
期刊：
The Journal of pharmacology and experimental therapeutics
影响因子：
--
作者：
Beardsley,PM;Balster,RL;Salay,JM
通讯作者：
Salay,JM
GBR 12909 辨别刺激作用的药理学特征。
DOI：
--
发表时间：
1991
期刊：
The Journal of pharmacology and experimental therapeutics
影响因子：
--
作者：
Melia,KF;Spealman,RD
通讯作者：
Spealman,RD