The relationship between risk-taking propensity and the COMT Val158Met polymorphism among early adolescents as a function of sex
The relationship between risk-taking propensity and the COMT Val158Met polymorphism among early adolescents as a function of sex
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DOI：
10.1016/j.jpsychires.2012.04.010
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发表时间：
2012-07-01
影响因子：
4.8
通讯作者：
Lejuez, C. W.
中科院分区：
文献类型：
--
作者：
Amstadter, Ananda B.;MacPherson, Laura;Lejuez, C. W.
虽然青少年经常从事各种危险的行为，很多仍然未知的具体病因，这种倾向。候选遗传变异，如COMT瓦尔（158）Met多态性，可能与冒险倾向有关，特别是因为这种变异与影响包括前额皮质在内的区域中多巴胺功能的功能性酶差异有关。本研究旨在探讨COMT瓦尔（158）Met变异与社区样本青年冒险倾向的关系。作为一项关于青少年风险行为的大型纵向研究的一部分，来自大都市华盛顿地区的223名青少年（平均年龄11.3岁）完成了一项风险倾向的测量，即气球模拟风险任务-青年版（BART-Y），并提供唾液样本进行DNA提取和基因分型。结果表明，女性，而不是男性，谁是COMT（158）甲硫氨酸等位基因携带者有较高的风险承担倾向评分的BART-Y相比，瓦尔纯合子。还对111名欧洲裔美国参与者进行了分析，结果与全样本分析结果一致。这项研究代表了第一次调查的风险承担倾向的遗传基础，测量的行为任务，在青年。鉴于样本较小，结果应被视为相当初步的。的影响进行了讨论。(C)2012爱思唯尔有限公司保留所有权利。
Although adolescents frequently engage in a variety of risky behaviors, much remains unknown about the specific etiologies of such tendencies. Candidate genetic variants, such as the COMT Val(158)Met polymorphism, may be related to risk-taking propensity, particularly as this variant is linked to functional enzymatic differences influencing dopamine function in regions including the prefrontal cortex. The present study aimed to examine the COMT Val(158)Met variant in relation to risk-taking propensity in a community sample of youth. As part of a larger longitudinal study on adolescent risk behaviors, 223 youths (average age 11.3 years) from the metropolitan Washington D.C. area completed a measure of risk-taking propensity, the Balloon Analog Risk Task-Youth Version (BART-Y), and provided saliva samples for DNA extraction and genotyping. Results indicate that females, but not males, who are carriers of the COMT (158)Met allele had higher risk-taking propensity scores on the BART-Y compared to Val homozygotes. Analyses were also conducted in the 111 European American participants, and results were consistent with those of the full sample analyses. This study represents the first investigation of a genetic substrate of risk-taking propensity, measured by a behavioral task, in youth. Results should be taken as quite preliminary, given the small sample. Implications are discussed. (C) 2012 Elsevier Ltd. All rights reserved.