Effect of aerobic exercise intensity on glycemic control in type 2 diabetes: a meta-analysis of head-to-head randomized trials
Effect of aerobic exercise intensity on glycemic control in type 2 diabetes: a meta-analysis of head-to-head randomized trials
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DOI：
10.1007/s00592-016-0870-0
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发表时间：
2016-10-01
影响因子：
3.8
通讯作者：
Boule, Normand G.
中科院分区：
文献类型：
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作者：
Liubaoerjijin, Yilina;Terada, Tasuku;Boule, Normand G.
对比较不同强度的有氧运动训练对 2 型糖尿病患者血糖控制的影响的头对头试验进行荟萃分析。检索了截至 2016 年 1 月的数据库，包括 MEDLINE 和 EMBASE。确定了持续时间至少 12 周的随机试验，比较了两种不同强度的运动干预措施。两名评审员独立地从符合条件的试验中提取数据。使用固定效应模型，计算不同运动强度之间的加权平均差 (WMD)，以了解糖化血红蛋白 (HbA1c) 的变化以及空腹血糖和空腹胰岛素等次要结果。八项研究总共有 235 名参与者符合资格。运动干预持续12周至6个月。不同研究中规定的运动强度各不相同。四项研究通过进行间歇训练来利用短时间的剧烈运动强度。总体而言，与较低强度运动相比，较高强度运动可显着降低 HbA1c（WMD = -0.22 %；95 % 置信区间 [-0.38，-0.06]；或 -2.4 mmol/mol [-4.15，-0.66]，I (2) = 0）。试验中坚持运动和退出的比例没有差异。在这些采用选定纳入标准的小型试验中，没有报告不良事件。尽管我们的荟萃分析样本量有限，但增加运动强度可以安全地促进一些 2 型糖尿病患者 HbA1c 的降低。人们使用了不同的方法来增加运动强度（即一些使用间歇训练，而另一些则使用更高强度的连续运动）。然而，目前尚不清楚哪种形式（如果有的话）会带来最有利的结果。
To conduct a meta-analysis of head-to-head trials comparing aerobic exercise training of different intensities on glycemic control in type 2 diabetes.Databases, including MEDLINE and EMBASE, were searched up to January 2016. Randomized trials of at least 12 weeks in duration that compared two exercise interventions of different intensities were identified. Two reviewers independently extracted data from eligible trials. Using fixed effect model, weighted mean differences (WMD) between different exercise intensities were calculated for changes in glycated hemoglobin (HbA1c) and secondary outcomes, such as fasting glucose and fasting insulin.Eight studies with a total of 235 participants were eligible. The exercise interventions lasted from 12 weeks to 6 months. The prescribed exercise intensities varied among studies. Four studies utilized vigorous exercise intensities for short durations by performing interval training. Overall, higher-intensity exercise resulted in a greater reduction in HbA1c compared to lower-intensity exercise (WMD = -0.22 %; 95 % confidence interval [-0.38, -0.06]; or -2.4 mmol/mol [-4.15, -0.66], I (2) = 0). Adherence to exercise and proportion of dropouts did not differ within trials. No adverse events were reported in these small trials with selected inclusion criteria.Although our meta-analysis had a limited sample size, increasing exercise intensity safely accentuated reductions in HbA1c in some people with type 2 diabetes. Different approaches have been used to increase exercise intensity (i.e., some used interval training, whereas others used higher-intensity continuous exercise). However, at this time, it is unclear which form, if any, leads to the most favorable results.