Insulin receptors: differences in structural organization on adipocyte and liver plasma membranes.
Insulin receptors: differences in structural organization on adipocyte and liver plasma membranes.
复制标题
胰岛素受体：脂肪细胞和肝质膜上结构组织的差异。
DOI：
10.1126/science.7003710
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发表时间：
1980
期刊：
影响因子：
--
通讯作者：
Smith,RM
中科院分区：
文献类型：
--
作者：
Jarett,L;Schweitzer,JB;Smith,RM
用铁蛋白-胰岛素法比较了脂肪细胞膜和肝细胞膜胰岛素受体位点的分布。脂肪细胞上三分之二的胰岛素受体以两个或两个以上的群体出现，而肝脏上多达三分之二的受体以单一受体出现。铁蛋白-胰岛素未引起任一组织中受体位点的聚集。脂肪细胞膜上天然存在的受体群可能在脂肪细胞对胰岛素的更大敏感性中起作用。
Comparison was made of the distribution of the insulin receptor sites on adipocyte and liver plasma membranes by using ferritin-insulin. Two-thirds of the occupied insulin receptors on adipocytes occurred in groups of two or more whereas up to two-thirds of the receptors on liver occurred as single receptors. Ferritin-insulin did not cause aggregation of the receptor sites in either tissue. The naturally occurring groups of receptors on adipocyte membranes may play a role in the greater sensitivity of adipocytes to insulin.