Improved visualization of carcinoid liver metastases by indium-111 pentetreotide scintigraphy following treatment with cold somatostatin analogue
Improved visualization of carcinoid liver metastases by indium-111 pentetreotide scintigraphy following treatment with cold somatostatin analogue
复制标题
使用冷生长抑素类似物治疗后，通过 indium-111 pentetreotide 闪烁扫描改善类癌肝转移的可视化
DOI：
10.1007/bf00209003
复制
发表时间：
1993
期刊：
影响因子：
--
通讯作者：
H. Bihl
中科院分区：
文献类型：
--
作者：
U. Dörr;U. Räth;M. Sautter‐Bihl;G. Guzmán;Guzman Bach;H. Adrian;H. Bihl
对5例中肠类癌肝转移患者在奥曲肽治疗前和治疗期间进行了生长抑素受体核素扫描。奥曲肽处理显著改变了~(111)In-戊四肽的生物分布。肝、脾、肾放射性降低，肝转移灶对比增强。在一名患者中，只有在奥曲肽治疗期间才能检测到肝转移。这些数据表明，生长抑素受体核素显像诊断类癌肝转移的可靠性不一定会受到奥曲肽治疗的影响。由于不同的生物分布，在奥曲肽治疗期间，肝转移的检测甚至可能会有所改善。
Five patients with hepatic metastases of midgut carcinoid underwent somatostatin receptor scintigraphy with indium-111 pentetreotide before and during treatment with octreotide. Octreotide treatment changed the biodistribution of111In-pentetreotide significantly. Whereas the radioactivity in liver, spleen and kidney decreased, hepatic metastases showed increased contrast. In one patient, liver metastases could only be detected during octreotide treatment. These data suggest that the diagnostic reliability of somatostatin receptor scintigraphy in carcinoid liver metastases is not necessarily compromised by octreotide therapy. Because of different biodistributions, the detection of liver metastases may even be improved during octreotide therapy.