Human t-cell lymphotropic virus type I (HTLV-I) - Related clinical and laboratory findings for HTLV-I-infected blood donors
Human t-cell lymphotropic virus type I (HTLV-I) - Related clinical and laboratory findings for HTLV-I-infected blood donors
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DOI：
10.1097/00126334-200303010-00013
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发表时间：
2003-03-01
影响因子：
3.6
通讯作者：
Osame, M
中科院分区：
文献类型：
--
作者：
Furukawa, Y;Kubota, R;Osame, M
本文报告了111例献血员感染人类T淋巴细胞病毒Ⅰ型（HTLV-Ⅰ）的临床和实验室检查结果。有成人T细胞白血病（ATL）或HTLV-1相关脊髓病/热带痉挛性下肢轻瘫（HAM/TSP）家族史的受试者中HTLV-1前病毒载量往往高于无这些疾病家族史的受试者。3例无症状ATL患者，4例有葡萄膜炎病史，7例下肢反射亢进，3例夜间尿频。下肢反射亢进受试者的平均CD 4细胞/CD 8细胞比率+/- SD（1.3 +/- 0.2）显著低于（p <0.0001）无任何临床异常的受试者（1.7 +/- 0.6），表明下肢反射亢进受试者已经存在某些免疫异常。在这项研究中，丈夫和妻子之间HTLV-1感染的一致性低于以前的研究。HTLV-I tax A感染的供体（6名供体中的3名[50%]）中HTLV-I相关炎症症状比HTLV-I tax B感染的供体（105名供体中的10名[9.5%]）更常见（p = 0.021，Fisher精确检验; OR = 9.5; 95% CI，1.7-53.5），表明根据病毒基因型，HTLV-I相关症状的风险不同。
Clinical and laboratory findings were examined for 111 human T-cell lymphotropic virus type I (HTLV-I)-infected blood donors. HTLV-1 provirus loads in subjects with a family history of adult T-cell leukemia (ATL) or HTLV-I-associated myelopathy/tropical spastic paraparesis (HAM/TSP) tended to be higher than those in subjects without a family history of these conditions. There were 3 asymptomatic patients with ATL, 4 with a history of uveitis, 7 with hyperreflexia in the lower limbs, and 3 with urinary frequency in the night. The mean CD4 cell/CD8 cell ratio +/- SD was significantly lower (p < .0001) in subjects with hyperreflexia in the lower limbs (1.3 +/- 0.2) than in subjects without any clinical abnormalities (1.7 +/- 0.6), suggesting that subjects with hyperreflexia in the lower limbs already have some immunologic abnormalities. The concordance of HTLV-1 infection between husband and wife was lower in this study than in a previous study. HTLV-I-related inflammatory symptoms were more frequent (p = .021, Fisher exact test; OR = 9.5; 95% CI, 1.7-53.5) in HTLV-I tax A-infected donors (3 [50%] of 6 donors) than in HTLV-I tax B-infected donors (10 [9.5%] of 105 donors), suggesting different risks of HTLV-I-related symptoms according to the virus genotype.