Total and regional gray matter volume is not related to APOE*E4 status in a community sample of middle-aged individuals
Total and regional gray matter volume is not related to APOE*E4 status in a community sample of middle-aged individuals
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DOI：
10.1093/gerona/63.5.501
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发表时间：
2008-05-01
影响因子：
5.1
通讯作者：
Easteal, Simon
中科院分区：
文献类型：
--
作者：
Cherbuin, Nicolas;Anstey, Kaarin J.;Easteal, Simon
背景。 APOE*E4 等位基因与更大的灰质萎缩和阿尔茨海默病有关。本研究的目的是调查脑灰质萎缩与 APOE*E4 基因型之间的关系是否也存在于社区居住的、非痴呆的 60 至 64 岁队列中。方法。在 331 个颅骨 T1 加权磁共振成像 (MRI) 扫描中手动追踪和分析海马和杏仁核体积，以检测与 APOE*E4 基因型相关的差异。应用基于体素的形态测量（VBM）分析来检测区域灰质体积差异。结果。 APOE*E4 携带者和非携带者之间未检测到总灰质体积、海马灰质体积或杏仁核灰质体积差异。结论。在 60 至 64 岁的非痴呆人群中，使用感兴趣区域分析和 VBM 均未发现 APOE 基因型与灰质体积之间存在关联。
Background. The APOE*E4 allele has been associated with greater gray matter atrophy and with Alzheimer's disease. The aim of this study was to investigate whether the relationship between cerebral gray matter atrophy and APOE*E4 genotype was also present in a community-dwelling, nondemented 60- to 64-year-old cohort.Methods. Hippocampal and amygdalar volumes were manually traced and analyzed on 331 cranial T1-weighted magnetic resonance imaging (MRI) scans to detect differences associated with APOE*E4 genotype. Voxel-based morphometric (VBM) analyses were applied to detect regional gray matter volume differences.Results. No total, hippocampal, or amygdalar gray matter volume difference was detected between APOE*E4 carriers and noncarriers.Conclusions. In nondemented 60- to 64-year-olds, there was no association between APOE genotype and gray matter volume using both region-of-interest analysis and VBM.