Diet, bowel function, fecal characteristics, and large bowel cancer in Denmark and Finland.
Diet, bowel function, fecal characteristics, and large bowel cancer in Denmark and Finland.
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丹麦和芬兰的饮食、肠道功能、粪便特征和大肠癌。
DOI：
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发表时间：
1982
期刊：
影响因子：
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通讯作者：
J. Wahrendorf
中科院分区：
文献类型：
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作者：
O. M. Jensen;R. Maclennan;J. Wahrendorf
在哥本哈根、Them（丹麦农村）、赫尔辛基和帕里卡拉（芬兰农村）这 4 个地区随机挑选了 30 名年龄在 50-59 岁之间的男性，以确定饮食、肠道传输时间、粪便量、粪便细菌学、胆汁酸浓度和尿液中挥发性酚的产生与大肠癌风险的关系。发现所有 4 个区域的平均每日脂肪摄入量都很高，并且区域之间没有差异。低发病率地区的饱和脂肪酸消耗量高于高发病率地区。帕里卡拉低发区的非淀粉多糖（膳食纤维的主要成分）、碳水化合物和蛋白质（主要是牛奶）的摄入量高于哥本哈根高发区。高发区粪便胆汁酸浓度高于低发区，其他2个地区处于中间值。粪便量与结直肠癌发病率呈负相关。在粪便细菌学或食品诱变活性方面没有观察到差异。这些结果表明，尽管膳食脂肪、蛋白质和肉类摄入量较高，但人群患结直肠癌的风险较低。膳食碳水化合物和纤维可能被认为具有保护作用。限制结直肠癌风险的一种机制可能是此类摄入导致粪便量的增加，因为粪便量的增加会稀释高脂肪饮食受试者增加的结肠胆汁酸浓度。
Some 30 randomly selected men, aged 50-59 years, were investigated in each of 4 areas--Copenhagen, Them (rural Denmark), Helsinki, and Parikkala (rural Finland)--to determine the relationship of diet, gut transit time, fecal bulk, fecal bacteriology, bile acid concentration, and urinary volatile phenol production to large bowel cancer risk. Average daily fat intake was found to be high in all 4 areas, and no differences emerged between areas. Saturated fatty acid consumption was higher in low-incidence areas than in high-incidence areas. Intakes of nonstarch polysaccharides (the main component of dietary fiber), carbohydrate, and protein (mainly milk) were higher in the low-incidence area of Parikkala than in the high-incidence area of Copenhagen. The fecal bile acid concentration was higher in the high-incidence area than in the low-incidence area, with the other 2 areas having intermediate values. Fecal bulk showed an inverse association with colorectal cancer incidence. No differences were observed with regard to fecal bacteriology or mutagenic activity of the foods. These results indicate that a population can have a low risk of colorectal cancer despite a high intake of dietary fat, protein, and meat. Dietary carbohydrate and fiber may be considered protective. One mechanism limiting colorectal cancer risk could be the increase in fecal bulk resulting from such intakes, since increased fecal bulk dilutes the increased colonic bile acid concentrations of subjects on high-fat diets.