Cerebellar contributions to orthographic working memory: A single case cognitive neuropsychological investigation.
Cerebellar contributions to orthographic working memory: A single case cognitive neuropsychological investigation.
复制标题
小脑对拼写工作记忆的贡献：单例认知神经心理学调查。
DOI：
10.1016/j.neuropsychologia.2022.108242
复制
发表时间：
2022
期刊：
影响因子：
2.6
通讯作者：
Fischer-Baum,Simon
中科院分区：
文献类型：
--
作者：
Paul,Sachi;Baca,Elizabeth;Fischer-Baum,Simon
单例认知神经心理学调查涉及个体参与者水平上认知障碍的精确表征。这种深度的数据精确性为复杂任务的认知和神经基础提供了更细致的理解，并继续为认知神经科学的理论提供独特的见解。在这里，我们提出了一个单独的案例研究，f.r.，谁遭受了中风，导致慢性阅读和写作问题，包括损伤的正字法工作记忆系统提出参与书面语言的产生和理解。以前报道过有类似认知障碍的个体通常有左顶叶病变。然而，f.r.的正字法工作记忆缺陷是由于右小脑的损伤造成的，特别是在结构和功能上都与左顶叶相连的区域，在之前的写作功能磁共振成像研究的meta分析中，该区域被确定为拼写网络的一部分。根据这种损伤-症状的关联，我们认为正字法工作记忆是由皮质-小脑回路提供的，回路中任何一点的损伤都会导致该功能的损害。这样的结论是由这种单一病例方法的观察结果所证实的，我们认为，如果将F.R.纳入一个更大、更浅的群体研究，这些观察结果可能会被遗漏。除了阐明我们对拼写的神经基础的理解之外，这个案例研究还证明了单个案例神经心理学可以继续给认知神经科学带来的价值。
Single case cognitive neuropsychological investigations involve the precise characterization of cognitive impairment at the level of an individual participant. This deep data precision affords a more fine-grained understanding of the cognitive and neural underpinnings of complex tasks, and continues to provide unique insights that inform theory in cognitive neuroscience. Here, we present a single case study of an individual, F.R., who suffered a stroke that led to chronic reading and writing problems that include an impairment to the orthographic working memory system proposed to be involved in both written language production and comprehension. Individuals who have been previously reported with a similar cognitive impairment commonly have left parietal lesions. However, F.R.’s orthographic working memory deficit resulted from damage to the right cerebellum, specifically to a region that is both structurally and functionally connected to the left parietal lobe and has been identified as part of the spelling network in previous meta-analyses of writing fMRI studies. From this lesion-symptom association, we argue that orthographic working memory is subserved by a cortical-cerebellar circuit, with damage at any point in the circuit resulting in an impairment to this function. Such a conclusion is warranted by observations from this single case approach, and we argue that these observations would likely have been missed if F.R. had been included in a larger, shallower group study. In addition to elucidating our understanding of the neural basis of spelling, this case study demonstrates the value that single case neuropsychology can continue to bring to cognitive neuroscience.