Gender Differences in Pulmonary Function, Respiratory Symptoms, and Macrophage Proteomics among HIV-Infected Smokers.
Gender Differences in Pulmonary Function, Respiratory Symptoms, and Macrophage Proteomics among HIV-Infected Smokers.
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感染艾滋病毒的吸烟者肺功能、呼吸道症状和巨噬细胞蛋白质组学的性别差异。
DOI：
10.1155/2014/613689
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发表时间：
2014
期刊：
影响因子：
3.2
通讯作者：
Diaz,PhilipT
中科院分区：
文献类型：
--
作者：
Rahmanian,ShivaD;Wood,KarenL;Lin,Shili;King,MarkA;Horne,April;Yang,Shangbin;Wu,HaifengM;Diaz,PhilipT
背景HIV感染受试者的肺气肿发生率增加。在COPD表型表达和诊断方面存在已知的性别差异，但这在与HIV相关的肺部疾病中没有得到很好的表征。我们分析了一组有COPD发展风险的人群（HIV感染的吸烟者），以确定肺部症状、肺功能检查和HRCT表现的性别差异。这是一项2006年至2010年进行的前瞻性研究的横断面基线分析。我们对243名HIV感染的吸烟者进行了症状、肺功能和计算机断层扫描评估。在一个子集进行支气管肺泡灌洗与蛋白质组学分析他们的肺泡巨噬细胞。大多数参与者为男性，213人（87.6%）。男性咳嗽和痰的比例明显较高。男性FEV1较女性低，RV较高。蛋白质组学分析显示29种蛋白质在男性中至少高出2倍，13种蛋白质在女性中表达更高。在这组HIV感染的吸烟者中，男性的气道症状和肺功能检查异常高于女性。这些性别差异可能是由于该组中某些蛋白质的差异表达。
Background. HIV‐infected subjects have an increased incidence of pulmonary emphysema. There are known gender differences in COPD phenotypic expression and diagnosis, but this is not well characterized in lung disease related to HIV. We analyzed a group at risk for the development of COPD (HIV‐infected smokers) to determine gender differences in pulmonary symptoms, pulmonary function tests, and HRCT appearances.Methods. This was a cross‐sectional, baseline analysis of a prospective study performed between 2006 and 2010. We performed symptomatic, pulmonary function, and computed tomography assessments in 243 HIV‐infected smokers. In a subset bronchoalveolar lavage was performed with proteomic analysis of their alveolar macrophages.Results. The majority of the participants were male 213 (87.6%). There was significantly higher percentage of cough and phlegm production in males. There was also a lower FEV1 and a higher RV in males than females. Proteomic analysis revealed 29 proteins with at least a 2‐fold higher expression in males and 13 identified proteins that were higher in females.Conclusions. In this group of HIV‐infected smokers, airway symptoms and pulmonary function test abnormalities were higher in men than women. These gender differences may be due to differential expression of certain proteins in this group.