The transcriptional STAT3 is a potential target, whereas transcriptional STAT5A/5B/6 are new biomarkers for prognosis in human breast carcinoma.
The transcriptional STAT3 is a potential target, whereas transcriptional STAT5A/5B/6 are new biomarkers for prognosis in human breast carcinoma.
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转录 STAT3 是一个潜在靶点，而转录 STAT5A/5B/6 是人类乳腺癌预后的新生物标志物。
DOI：
10.18632/oncotarget.16748
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发表时间：
2017-05-30
期刊：
影响因子：
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通讯作者：
Huang YT
中科院分区：
文献类型：
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作者：
Wu HT;Liu J;Li GW;Shen JX;Huang YT
信号转导和转录激活因子（SignalTransducerandActivatorsofTranscription，STAT）是一组转录因子，参与多种细胞功能。来自细胞系、小鼠模型和人体组织的证据表明这些转录因子参与了乳腺癌的发生。然而，7个STAT的不同表达模式和预后价值仍有待阐明。在本研究中，我们通过ONCOMINE，bc-GenExMiner，Kaplan-Meier Plotter和cBioPortal挖掘乳腺癌（BC）患者中STAT的转录和生存数据。结果发现，与正常组织相比，乳腺癌组织中STAT 1/2表达上调，STAT 3/4/5A/5 B表达下调。STAT 5A/5 B/6的表达与组织分化程度的降低有关。在Kaplan-Meier生存分析数据库中，STAT 2/4/5A/5 B/6的高转录水平与所有BC患者的无复发生存率（RFS）相关。相反，高STAT 3预测BC患者的RFS较短，表明STAT 3是BC患者精确治疗的潜在靶点。这些数据也提供了STAT 5A/5 B/6作为BC预后的新生物标志物。
Signal Transducer and Activators of Transcription (STAT) is a set of transcription factors, involved in diverse cellular functions. Evidences from cell lines, mouse models and human tissues implicate these transcription factors in the oncogenesis of breast cancer. However, the diverse expression patterns and prognostic values of 7 STATs remain to be elucidated. In the current study, we mined the transcriptional and survival data of STATs in patients with breast carcinoma (BC) through ONCOMINE, bc-GenExMiner, Kaplan-Meier Plotter and cBioPortal. It was found that STAT1/2 were up-regulated, whereas STAT3/4/5A/5B were down-regulated in BC patients compared with the normal tissues. The expressions of STAT5A/5B/6 were correlated with decreased levels of histological differentiation. In survival analyses through the Kaplan-Meier plotter database, high transcription levels of STAT2/4/5A/5B/6 were associated with better relapse-free survival (RFS) in all BC patients. Conversely, high STAT3 predicted shorter RFS in BC patients, suggesting that STAT3 is potential targets for precision therapy to BC patients. These data also provided STAT5A/5B/6 as new biomarker for BC prognosis.