SIMULATION MODELING OF CARCINOGENESIS
SIMULATION MODELING OF CARCINOGENESIS
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DOI：
10.1016/0041-008x(92)90013-i
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发表时间：
1992-03-01
影响因子：
3.8
通讯作者：
COHEN, SM
中科院分区：
文献类型：
--
作者：
ELLWEIN, LB;COHEN, SM
使用时变模型变量之间的递归关系以数学方式描述致癌作用的离散时间模拟模型。细胞行为的动态表现在一个生物框架内，该框架包含两个不可逆且可遗传的遗传变化。处理对照动物组和实验动物组的经验数据和生物学假设一起用于建立模型输入变量的值。这些变量的估计是模拟过程中不可或缺的一部分，如逐步详细描述的那样。雄性 F344 大鼠的肝癌发生为七种建模场景提供了基础，这些场景说明了细胞增殖、遗传毒性和肿瘤风险之间关系的复杂性。
A discrete-time simulation model of carcinogenesis is described mathematically using recursive relationships between time-varying model variables. The dynamics of cellular behavior is represented within a biological framework that encompasses two irreversible and heritable genetic changes. Empirical data and biological supposition dealing with both control and experimental animal groups are used together to establish values for model input variables. The estimation of these variables is integral to the simulation process as described in step-by-step detail. Hepatocarcinogensis in male F344 rats provides the basis for seven modeling scenarios which illustrate the complexity of relationships among cell proliferation, genotoxicity, and tumor risk.