Signal transduction via the interleukin-4 receptor and its correlation with atopy.
Signal transduction via the interleukin-4 receptor and its correlation with atopy.
复制标题
通过 IL-4 受体的信号转导及其与特应性的相关性。
DOI：
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发表时间：
1999
影响因子：
5.4
通讯作者：
T. Shirakawa
中科院分区：
文献类型：
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作者：
Kenji Izuhara;T. Shirakawa
IL-4和IL-13是一种独特的细胞因子，它们能诱导B细胞的IgE合成和T细胞的TH2型分化。这两种细胞因子都通过与靶细胞上的功能性受体结合来发挥其生物学活性。这些受体被认为是以异二聚体的形式组成的，都含有IL-4Rα链(IL-4Rα)作为组成部分。在IL-4和IL-13的信号转导分子中，STAT6被这些细胞因子激活并招募到IL-4Rα，对这些细胞因子的生物学活性是必不可少的。特应性是一种遗传性倾向，以哮喘、鼻炎和湿疹为基础，并产生针对常见抗原的高非特异性IgE和/或高特异性IgE。根据IL-4和IL-13信号转导的分子机制以及一些遗传学研究，IL-4Rα被认为是导致特应性的一个基因。存在于IL-4Rpha基因Ile50Val的一种多态被证实与特应性的遗传和功能有关。相反，IL-4Rpha基因的另一种多态Arg551Gln与特应性的相关性仍存在争议。这些研究中使用的策略应该有助于识别与特应性反应有关的其他基因。
IL-4 and IL-13 are unique cytokines, in that they induce IgE synthesis in B cells and TH2 type differentiation in T cells. Both cytokines exert their biological activities by binding to their functional receptors on target cells. These receptors are thought to be composed as heterodimers, both having the IL-4R alpha chain (IL-4Ralpha) as a component. Among the signal-transducing molecules of IL-4 and IL-13, Stat6, which is activated by these cytokines and recruits to IL-4Ralpha, is essential for the biological activities of these cytokines. Atopy is an inherited tendency, underlying asthma, rhinitis, and eczema, and generating high non-specific IgE and/or high specific IgE against common antigens. Based on information on the molecular mechanism of the signal transduction of IL-4 and IL-13 and on some genetic studies, IL-4Ralpha was assumed to be one gene giving rise to atopy. One polymorphism existing in the IL-4Ralpha gene, Ile50Val, is verified to correlate with atopy by both genetic and functional aspects. On the contrary, the correlation between another polymorphism on the IL-4Ralpha gene, Arg551Gln, and atopy is still controversial. The strategy used in these studies should lead to identification of other genes involved in atopy.