Calcineurin Orchestrates Hyphal Growth, Septation, Drug Resistance and Pathogenesis of Aspergillus fumigatus: Where Do We Go from Here?
Calcineurin Orchestrates Hyphal Growth, Septation, Drug Resistance and Pathogenesis of Aspergillus fumigatus: Where Do We Go from Here?
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DOI：
10.3390/pathogens4040883
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发表时间：
2015-12-16
期刊：
影响因子：
--
通讯作者：
Steinbach WJ
中科院分区：
文献类型：
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作者：
Juvvadi PR;Steinbach WJ
鉴于这些真菌引起人类感染的普遍性和频率，对属于子囊菌门的真菌病原体的研究至关重要。在这些物种中，烟曲霉会引起侵袭性曲霉病，这是免疫功能低下患者死亡的主要原因。烟曲霉发病机制的基础是菌丝生长。然而，人们对菌丝生长和毒力的确切机制知之甚少。在过去的 10 年里，我们对鉴定负责菌丝生长、耐药性和毒力的分子靶点的研究阐明了钙调神经磷酸酶是控制这些过程的关键信号分子。在这篇综述中，我们总结了关于钙调神经磷酸酶对烟曲霉菌丝生长和分隔的重要性的重要发现，并提出了利用这一途径设计新的真菌特异性疗法的未来前景。
Studies on fungal pathogens belonging to the ascomycota phylum are critical given the ubiquity and frequency with which these fungi cause infections in humans. Among these species, Aspergillus fumigatus causes invasive aspergillosis, a leading cause of death in immunocompromised patients. Fundamental to A. fumigatus pathogenesis is hyphal growth. However, the precise mechanisms underlying hyphal growth and virulence are poorly understood. Over the past 10 years, our research towards the identification of molecular targets responsible for hyphal growth, drug resistance and virulence led to the elucidation of calcineurin as a key signaling molecule governing these processes. In this review, we summarize our salient findings on the significance of calcineurin for hyphal growth and septation in A. fumigatus and propose future perspectives on exploiting this pathway for designing new fungal-specific therapeutics.