Closed circuit MR compatible pulsatile pump system using a ventricular assist device and pressure control unit
Closed circuit MR compatible pulsatile pump system using a ventricular assist device and pressure control unit
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DOI：
10.1002/mrm.22983
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发表时间：
2012-01-01
影响因子：
3.3
通讯作者：
Markl, M.
中科院分区：
文献类型：
--
作者：
Lorenz, R.;Benk, C.;Markl, M.
本研究的目的是评估一种使用脑室辅助装置作为脉动流量泵的闭路MR兼容气动驱动泵系统的性能，用于体外三维流动模拟。此外，在流量回路中还集成了压力控制单元。使用狭窄模体(60%管腔狭窄)评估泵系统的性能及其测试-再测试的可靠性。BlandAltman分析显示，体外流量测量具有良好的测试可靠性(平均差值=-0.016 m/S，协议限=+/-0.047 m/S)。此外，一个正常胸主动脉的体外快速原型模型被集成到流动回路中，以直接比较同一受试者的流动特性和体内数据。在体外模型的升主动脉上安装气动辅助装置，模拟心脏跳动。在健康的主动脉的下降部分，整合了一个柔性狭窄来模拟主动脉缩窄。体内外比较，平均血流速度有显著相关性(P=0.002.0 5)。对缩窄程度增加的模拟导致了预期的流动模式的变化，如狭窄后区域的射流和速度的增加。Magn Reson Med，2011。(C)2011年Wiley-Liss，Inc.
The aim of this study was to evaluate the performance of a closed circuit MR compatible pneumatically driven pump system using a ventricular assist device as pulsatile flow pump for in vitro 3D flow simulation. Additionally, a pressure control unit was integrated into the flow circuit. The performance of the pump system and its test-retest reliability was evaluated using a stenosis phantom (60% lumen narrowing). BlandAltman analysis revealed a good testretest reliability (mean differences = -0.016 m/s, limits of agreement = +/- 0.047 m/s) for in vitro flow measurements. Furthermore, a rapid prototyping in vitro model of a normal thoracic aorta was integrated into the flow circuit for a direct comparison of flow characteristics with in vivo data in the same subject. The pneumatically driven ventricular assist device was attached to the ascending aorta of the in vitro model to simulate the beating left ventricle. In the descending part of the healthy aorta a flexible stenosis was integrated to model an aortic coarctation. In vivo and in vitro comparison showed significant (P = 0.002) correlations (r = 0.9) of mean velocities. The simulation of increasing coarctation grade led to expected changes in the flow patterns such as jet flow in the post-stenotic region and increased velocities. Magn Reson Med, 2011. (C) 2011 Wiley-Liss, Inc.