The respiratory epithelium. III. Histogenesis of epidermoid metaplasia and carcinoma in situ in the human.
The respiratory epithelium. III. Histogenesis of epidermoid metaplasia and carcinoma in situ in the human.
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呼吸道上皮。
DOI：
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发表时间：
1978
期刊：
影响因子：
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通讯作者：
Curtis C. Harris
中科院分区：
文献类型：
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作者：
Benjamin F. Trump;Elizabeth M. McDowell;Fred Glavin;Lucy A. Barrett;Peter J. Becci;Walter Schürch;Hans E. Kaiser;Curtis C. Harris
分析了人支气管上皮中表皮样化生和原位癌的组织发生。结论是表皮样化生和原位癌可以由粘液细胞的转化引起。这意味着一种类型的完全分化细胞直接转化为另一种类型。因此，该研究强调了粘液细胞的分化潜力，这些细胞可以分裂并经历杯状细胞增生和表皮样化生。表皮样化生是支气管损伤的常见反应。在我们的一系列病例中，这种情况在马里兰大学休克创伤科接受过气管插管或气管切开术并一直使用呼吸器维持的无肿瘤疾病的患者中尤其常见。未来的研究需要区分注定会变成恶性肿瘤的表皮样化生与不会变成恶性肿瘤的表皮样化生之间的差异（如果有的话）。这项研究中注意到的一个差异是，在没有肿瘤疾病的患者中，表皮样化生中没有明显的角化。
The histogenesis of epidermoid metaplasia and carcinoma in situ was analyzed in human bronchial epithelium. The conclusion is that epidermoid metaplasia and carcinoma in situ can result from conversion of mucous cells. This implies the direct transformation of one type of fully differentiated cell to another. The study therefore emphasizes the differentiation potentialities of the mucous cells that can divide and undergo goblet cell hyperplasia and epidermoid metaplasia. Epidermoid metaplasia is a common reaction to injury in the bronchus. In our series of cases it was especially frequent in patients without neoplastic disease who had undergone intratracheal intubation or tracheostomy and who had been maintained on a respirator in the Shock Trauma Unit, University of Maryland. Future studies will be required to distinguish the difference, if any, between epidermoid metaplasia destined to become malignant carcinoma and that which is not. One difference noted in this study was the absence of overt cornification in epidermoid metaplasia in patients without neoplastic disease.