The relationship between cigarette smoking and quality of life after lung cancer diagnosis
The relationship between cigarette smoking and quality of life after lung cancer diagnosis
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DOI：
10.1378/chest.126.6.1733
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发表时间：
2004-12-01
期刊：
影响因子：
9.6
通讯作者：
Sloan, JA
中科院分区：
文献类型：
--
作者：
Garces, YI;Yang, P;Sloan, JA
研究目的：描述吸烟与肺癌幸存者生活质量（QOL）之间的关系，采用肺癌症状量表（LCSS）测量。设计和设置：LCSS在1999年至2002年期间邮寄给符合条件的患者（1,506例患者）。通过单变量独立组检验和多变量线性模型比较不同吸烟组的LCSS评分（总的和个体QOL组分）。建模过程检查了年龄调整后的组间差异。性别，阶段。LCSS评估的时间。将LCSS评分转换为0至100分的量表，其中较高的LCSS评分对应于较低的QOL。组间10分的差异被定义为先验的临床显着。结果：在肺癌诊断的时间，18%的患者是从不吸烟者，58%是前吸烟者，24%是当前吸烟者。在随访评估时完成LCSS的调查受访者（1，028名受访者）中，平均年龄为65.2岁（SD，10.8岁），45%为女性。30%的基线当前吸烟者在随访评估时继续吸烟（即，持续吸烟者）。从不吸烟者和持续吸烟者的校正平均LCSS总分分别为17.6（SD，4.02）和28.7（SD，5.09）（p < 0.0001）。从不吸烟者和持续吸烟者之间的7个LCSS QOL组分（即食欲、疲劳、咳嗽、呼吸短促、肺癌症状、影响正常活动的疾病和总体QOL）在临床和统计学上存在差异（p < 0.001）。在疼痛或咯血方面未观察到临床显著差异。既往吸烟者的LCSS评分居中。每日吸烟包数或吸烟包年总数与校正scores.Conclusion：吸烟状态与生活质量之间的假设关系得到了相关研究的支持。我们的研究结果表明，肺癌诊断后持续吸烟会对生活质量评分产生负面影响。
Study objective: To describe the relationship between cigarette smoking and quality of life (QOL) among lung cancer survivors as measured by the lung cancer symptom scale (LCSS).Design and setting: The LCSS was mailed to eligible patients (1,506 patients) between 1999 and 2002. LCSS scores (total and individual QOL components) were compared among different groups of cigarette smokers via univariate independent group testing and multivariate linear models. The modeling process examined group differences adjusted for age. gender, stage. and time of LCSS assessment. LCSS scores were transformed onto a scale of 0 to 100 points in which higher LCSS scores corresponded to a lower QOL. A 10-point difference between groups was defined a priori as being clinically significant.Results: At the time of lung cancer diagnosis, 18% of the patients were never-smokers, 58% were former smokers, and 24% were current smokers. Among survey respondents completing the LCSS at follow-up assessment (1,028 respondents), the mean age was 65.2 years (SD, 10.8 years) and 45% were women. Thirty percent of baseline current smokers continued to smoke at the time of the follow-up assessment (ie, persistent smokers). The adjusted mean total LCSS scores for never-smokers and persistent smokers were 17.6 (SD, 4.02) and 28.7 (SD, 5.09), respectively (p < 0.0001). Seven of the individual LCSS QOL components (ie, appetite, fatigue, cough, shortness of breath, lung cancer symptoms, illness affecting normal activities, and overall QOL) were clinically and statistically (p < 0.001) different between never-smokers and persistent smokers. No clinically significant differences were noted for pain or hemoptysis. Former smokers had intermediate LCSS scores. No dose-response trends were observed between the number of packs of cigarettes smoked per day or the total number of pack-years smoked and the adjusted scores.Conclusion: The hypothesized relationship between smoking status and QOL was supported by this correlational study. Our findings suggest that persistent cigarette smoking after a lung cancer diagnosis negatively impacts QOL scores.