Hollow silica-polyelectrolyte composite nanoparticles for controlled drug delivery
Hollow silica-polyelectrolyte composite nanoparticles for controlled drug delivery
复制标题
用于控制药物输送的中空二氧化硅-聚电解质复合纳米颗粒
DOI：
10.1007/s10853-018-2996-7
复制
发表时间：
2019
影响因子：
4.5
通讯作者：
Guo Xuhong
中科院分区：
文献类型：
--
作者：
Yang Qingsong;Li Li;Zhao Fang;Han Haoya;Wang Weihua;Tian Yuchuan;Wang Yunwei;Ye Zhishuang;Guo Xuhong
刺激响应型给药系统由于其能够提高治疗效果和减少副作用而受到越来越多的关注。本文以聚苯乙烯（PS）为核，聚丙烯酸（PAA）为壳，以球形聚苯乙烯刷（SPB）为模板，成功制备了pH和谷胱甘肽（GSH）双重响应的药物载体--中空SiO2-β-Al 2 O3复合纳米粒。PAA链的存在和二氧化硅骨架中二硫键的引入赋予了复合纳米粒子pH和GSH双重响应特性，这一点通过动态光散射（DLS）和小角X射线散射（SAXS）得到了证实。以盐酸阿霉素（DOX）为模型药物，载药量和包封率分别可达43%和96%。考察了不同环境下的药物释放行为，结果表明，药物释放速率随着pH值的降低和还原型谷胱甘肽浓度的增加而增加。所制备的中空SiO2-PAA复合纳米粒具有作为药物控释载体的巨大潜力。
The stimulus-responsive drug delivery system has attracted increasing attention due to its ability to enhance therapeutic efficacy and reduce side effects. Herein, a pH and glutathione (GSH) dually responsive drug carrier, hollow silica–-polyelectrolyte composite nanoparticle, was successfully prepared by using a template of spherical polyelectrolyte brush (SPB) which consists of a polystyrene (PS) core and a densely grafted linear poly(acrylic acid) (PAA) shell. The existence of PAA chains and introduction of disulfide bonds in silica framework endow the composite nanoparticles with pH and GSH dually responsive properties which were confirmed by dynamic light scattering (DLS) and small-angle X-ray scattering (SAXS). With doxorubicin hydrochloride (DOX) as the model drug, the loading content and encapsulation efficiency could reach up to 43% and 96%, respectively. The drug release behavior was investigated under various environments, showing that the drug release rate increased with the decrease in pH value and the increase in GSH concentration. The prepared hollow SiO2–PAA composite nanoparticles possess a great potential as carriers for controlled drug delivery.