A simple tool for identifying unaffected women at a moderately increased or potentially high risk of breast cancer based on their family history
A simple tool for identifying unaffected women at a moderately increased or potentially high risk of breast cancer based on their family history
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DOI：
10.1016/s0960-9776(02)00285-0
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发表时间：
2003-04-01
期刊：
影响因子：
3.9
通讯作者：
Burgemeister, FC
中科院分区：
文献类型：
--
作者：
Fisher, TJ;Kirk, J;Burgemeister, FC
乳腺癌的家族史是临床管理的一个更重要的方面后，基因BRCA1和BRCA2的发现。作者开发了一份简短的问卷，根据近亲的乳腺癌病史对风险进行分类。这项研究是由559名在悉尼接受乳房X光检查的妇女完成的。澳大利亚23%的人报告有家族史，足以根据国家准则被归类为中度增加或潜在高风险（第二类或第三类）。只有29名妇女（5%）犯了错误，无法确定其风险类别。从89名妇女，44从第二类或第三类验证的答复，发现100%的协议与分类后，遗传咨询师采访。该问卷有可能根据妇女对其家族史的了解准确地分类风险，并可用于各种环境中，以确定可能需要进一步评估，管理和转诊建议的妇女。(C)2003爱思唯尔科技有限公司版权所有。
Family history of breast cancer is a more important aspect of clinical management following the discovery of the genes BRCA1 and BRCA2. The authors developed a short questionnaire to categorise risk according to breast cancer history in close relatives. It was completed by 559 women attending for screening mammograms in Sydney. Australia. Twenty-three per cent reported a family history sufficient to be classified at a moderately increased or potentially high risk according to national guidelines (category II or III). Only 29 women (5%) made errors such that their risk category could not be determined. Validation of responses from 89 women, 44 from category II or III, found 100% agreement with classification after interview by a genetic counsellor. This questionnaire has the potential to accurately triage risk based on a woman's knowledge of her family history, and could be used in a variety of settings to identify women who may require further assessment, management and referral advice. (C) 2003 Elsevier Science Ltd. All rights reserved.