RECEDING HORIZON CONTROL METHOD APPLIED TO ANTIVIRAL TREATMENT OF AIDS
RECEDING HORIZON CONTROL METHOD APPLIED TO ANTIVIRAL TREATMENT OF AIDS
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后退控制方法在艾滋病抗病毒治疗中的应用
DOI:
10.18514/mmn.2004.83
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发表时间:
2004
期刊:
影响因子:
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通讯作者:
A. Elaiw
中科院分区:
文献类型:
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作者:
A. Elaiw
This paper investigates the stabilization of a desired equilibrium point of a model describing the interaction of the immune system (CD4 cells and cyto- toxic T lymphocytes CTL) with human immunodeficiecy virus HIV with sampled- data controllers. The control variable is the drug dose. Two cases of anti-HIV drugs are considered: 1 reverse transcriptase inhibitors (RTI), and 2 protease in- hibitors (PI). The controller is constructed by a variant of the receding horizon con- trol (RHC) method. We use the results obtained by (3) giving su cient conditions which guarantee that the receding horizon controller that stabilizes the approximate discrete-time model also stabilizes the exact discrete-time model for su ciently small discretization parameters. Results of simulations are discussed. Mathematics Subject Classification: 93D15, 93C57, 92D30
DOI:
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发表时间:
2006
期刊:
影响因子:
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作者:
片山仁志;市川朗
通讯作者:
市川朗