Selenoproteins and their impact on human health through diverse physiological pathways
Selenoproteins and their impact on human health through diverse physiological pathways
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DOI：
10.1152/physiol.00021.2006
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发表时间：
2006-10-01
期刊：
影响因子：
8.4
通讯作者：
Beggs, Alan H.
中科院分区：
文献类型：
--
作者：
Hadaszadeh, Behzad M.;Beggs, Alan H.
在过去的几十年里，硒在人类健康中的重要性一直是许多研究的主题。据信硒的生理作用主要通过硒蛋白的功能发生，硒蛋白以一个或多个硒代半胱氨酸残基的形式掺入硒。最近在了解硒蛋白合成的复杂调节和硒蛋白家族的几个成员的功能特性方面的进展，有助于更好地理解硒在人类健康中的作用以及受这种微量元素影响的多种生理途径。
In the last few decades, the importance of selenium in human health has been the subject of numerous studies. It is believed that the physiological effects of selenium occur mainly through the function of selenoproteins, which incorporate selenium in the form of one or more selenocysteine residues. Recent advances in understanding the complex regulation of selenoprotein synthesis and functional characterization of several members of the selenoprotein family have contributed to an improved comprehension of the role(s) of selenium in human health and the great diversity of physiological pathways influenced by this trace element.