Microinfusion of protein kinase inhibitor H7 into the cerebellum impairs the acquisition but not the retention of classical eyeblink conditioning in rabbits
Microinfusion of protein kinase inhibitor H7 into the cerebellum impairs the acquisition but not the retention of classical eyeblink conditioning in rabbits
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DOI：
10.1016/s0006-8993(99)02429-4
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发表时间：
2000-02-21
期刊：
影响因子：
2.9
通讯作者：
Steinmetz, JE
中科院分区：
文献类型：
--
作者：
Chen, GX;Steinmetz, JE
在经典的眨眼条件反射过程中，将H7（一种通用蛋白激酶抑制剂）注入家兔小脑间位核区域。条件性眨眼反应的获得被H7输注延迟，但蛋白激酶抑制剂在渐进学习后输注时对学习反应的性能没有影响。这些数据表明，小脑中的蛋白激酶参与了可塑性过程，这是学习这种简单条件行为的基础，（C）2000 Elsevier Science B.V.保留所有权利。
Rabbits were infused with H7, a general protein kinase inhibitor, into the region of the cerebellar interpositus nucleus during classical eyeblink conditioning. Acquisition of the conditioned eyeblink response was delayed by the H7 infusion, but the protein kinase inhibitor had no effect on performance of the learned response when infused after asymptotic learning had been reached. These data indicate that protein kinases in the cerebellum are involved in plasticity processes that underlie the learning of this simple conditioned behavior, (C) 2000 Elsevier Science B.V. All rights reserved.