NEUROMEDIN-C - A BOMBESIN-LIKE PEPTIDE IDENTIFIED IN PORCINE SPINAL-CORD
NEUROMEDIN-C - A BOMBESIN-LIKE PEPTIDE IDENTIFIED IN PORCINE SPINAL-CORD
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DOI：
10.1016/0006-291x(84)91611-5
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发表时间：
1984-01-01
影响因子：
3.1
通讯作者：
MATSUO, H
中科院分区：
文献类型：
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作者：
MINAMINO, N;KANGAWA, K;MATSUO, H
从先前从猪脊髓中分离得到的神经药蛋白B的侧组分中，纯化了另一种十肽，该十肽对大鼠子宫平滑肌制备具有强效的刺激作用。经微测序和合成鉴定，该肽的氨基酸序列为：Gly-Asn-His-Trp-Ala-Val-Gly-His-Leu-Met-NH2。该肽与胃泌素肽的羧基末端序列相同，并以bombesin的特征方式对大鼠子宫表现出强大的收缩活性。该肽可能是哺乳动物神经通讯系统中的神经介质。该肽被命名为neuromedin C，因为它与神经medin B密切相关，最近发现神经medin B是一种类似炸弹蛋白的哺乳动物肽。
From a side fraction obtained in a previous isolation of neuromedin B from porcine spinal cord, another decapeptide was purified that exhibits a potent stimulant effect on the smooth muscle preparation of rat utrerus. By microsequencing and synthesis, the amino acid sequence of the peptide was identified as: Gly-Asn-His-Trp-Ala-Val-Gly-His-Leu-Met-NH2. This peptide was identical with the carboxyl-terminal subsequence of gastrin peptide, and displayed a potent contractile activity on rat uterus in the characteristic manner of bombesin. The peptide may be a neuromediator in the neural communication systems of mammals. The name neuromedin C is proposed for this peptide, since it is closely related to neuromedin B, recently identified as a bombesin-like mammalian peptide.