M48U1 CD4 mimetic has a sustained inhibitory effect on cell-associated HIV-1 by attenuating virion infectivity through gp120 shedding.
M48U1 CD4 mimetic has a sustained inhibitory effect on cell-associated HIV-1 by attenuating virion infectivity through gp120 shedding.
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DOI：
10.1186/1742-4690-10-12
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发表时间：
2013-02-01
期刊：
影响因子：
3.3
通讯作者：
Ariën KK
中科院分区：
文献类型：
--
作者：
Selhorst P;Grupping K;Tong T;Crooks ET;Martin L;Vanham G;Binley JM;Ariën KK
HIV-1 infected cells can establish new infections by crossing the vaginal epithelia and subsequently producing virus in a milieu that avoids the high microbicide concentrations of the vaginal lumen. To address this problem, here, we report that pretreatment of HIV-infected peripheral blood mononuclear cells (PBMCs) with a 27 amino acid CD4-mimetic, M48U1, causes dramatic and prolonged reduction of infectious virus output, due to its induction of gp120 shedding. M48U1 may, therefore, be valuable for prophylaxis of mucosal HIV-1 transmission.
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影响因子：
3.8
作者：
Di Fabio, S;Giannini, G;Vella, S
通讯作者：
Vella, S
影响因子：
3.3
作者：
Grupping, Katrijn;Selhorst, Philippe;Arien, Kevin K.
通讯作者：
Arien, Kevin K.
影响因子：
4.9
作者：
Selhorst, Philippe;Grupping, Katrijn;Vanham, Guido
通讯作者：
Vanham, Guido
影响因子：
5.4
作者：
Tong, Tommy;Crooks, Ema T.;Binley, James M.
通讯作者：
Binley, James M.
DOI：
10.1097/qad.0b013e32833424c8
发表时间：
2010-01-16
期刊：
AIDS (London, England)
影响因子：
--
作者：
Anderson DJ;Politch JA;Nadolski AM;Blaskewicz CD;Pudney J;Mayer KH
通讯作者：
Mayer KH