In vitro response of Escherichia coli to antibiotics and ultrasound at various insonation intensities
In vitro response of Escherichia coli to antibiotics and ultrasound at various insonation intensities
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DOI：
10.1177/088532829701200102
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发表时间：
1997-07-01
影响因子：
2.9
通讯作者：
Pitt, WG
中科院分区：
文献类型：
--
作者：
Williams, RG;Pitt, WG
植入医疗设备上的微生物感染很难治疗。应用 70 kHz 超声波照射庆大霉素治疗大大增强了抗生素在降低活细菌浓度方面的作用。超声波照射以各种声波强度进行，在没有抗生素的情况下，这些声波强度是非抑制性的。观察到协同杀伤是超声波强度的函数。在全强度 (4.5 W/cm(2)) 下实现了最大杀伤力（存活种群减少约 5 个对数），并随着功率密度的降低而减少。在最低强度（10 mW/cm(2)）下，未观察到明显的声波增强杀伤作用。
Microbial infections on implanted medical devices are difficult to treat. Application of 70 kHz ultrasonic irradiation to gentamicin treatment greatly enhanced the action of the antibiotic in terms of reduced viable bacterial concentrations. Ultrasonic irradiation was carried out at various insonation intensities that were noninhibitory in the absence of antibiotic. Synergistic killing was observed to be a function of ultrasonic intensity. Greatest killing (approximately 5 log reduction in viable population) was realized at full intensity (4.5 W/cm(2)), and decreased with reductions in power density. At lowest intensity (10 mW/cm(2)), no significant acoustic enhanced killing was noted.