Serotonin transporter gene (5-HTT) rs6354 polymorphism, job-related stress, and their interaction in burnout in healthcare workers in a Chinese hospital
Serotonin transporter gene (5-HTT) rs6354 polymorphism, job-related stress, and their interaction in burnout in healthcare workers in a Chinese hospital
复制标题
血清素转运蛋白基因（5-HTT）rs6354多态性、工作相关压力及其在中国医院医护人员职业倦怠中的相互作用
DOI：
10.1007/s00213-018-5009-2
复制
发表时间：
2018-11-01
影响因子：
3.4
通讯作者：
Zhang, Xiang Yang
中科院分区：
文献类型：
--
作者：
Cao, Zeyuan;Wu, Shuang;Zhang, Xiang Yang
目的研究表明，长期工作压力会导致工作倦怠，其发生可能受到遗传和环境因素的影响。倦怠与抑郁有关。本研究旨在探讨5-HTT基因rs6354多态性是否影响工作压力对职业倦怠的影响。方法采用Maslach职业倦怠量表（MBI）对某综合性医院712名医务人员的职业倦怠症状进行测量。压力使用House和Rizzo的工作压力量表，压力源使用Evers、Frese和库珀的压力源量表。结果工作压力因子分和6个压力源因子分与3个倦怠因子分之间的相关性均显著（P < 0.05）。5-HTT rs6354基因型对倦怠症状没有显著的主效应;然而，5-HTT rs6354和工作压力对倦怠有统计学显著的交互作用（F = 5.08，df = 2，369，p = 0.007）。低应激组中，G等位基因携带者的倦怠水平显著高于TT纯合子（F = 11.60，df = 1.48，p < 0.001）。相反，在高应激组中，G等位基因携带者的倦怠水平显著低于TT纯合子结论5-HTT基因rs6354多态性可能通过调节5-羟色胺转运体功能和神经传递调节工作压力对工作倦怠的影响，TT基因型个体对高应激的不利影响和低应激的有利影响的易感性均高于G等位基因个体，这支持了差异易感性假说。
Objective Many studies have reported that long-term exposure to job-related stress can lead to burnout, which may be influenced by genetic and environmental factors. Burnout correlates with depression. This study investigated whether one tag polymorphism rs6354 in 5-HTT gene modulated the influence of job-related stress on burnout in the medical professionals in a Chinese Han population, which to our best knowledge has not been explored.Methods Seven hundred twelve subjects were recruited from a general hospital and measured for burnout symptoms using the Maslach Burnout Inventory (MBI), the stress using the House and Rizzo's Work Stress Scale, and the stressors using the Evers, Frese, and Cooper's Sources of Pressure Scale. The 5-HTT rs6354 polymorphism was genotyped in 376 subjects.Results The majority of correlations between the work stress score or the six stressor scores and three burnout subscores were significant (all p < 0.05). There was no significant main effect of the 5-HTT rs6354 genotype on burnout symptoms; however, there was a statistically significant interaction between 5-HTT rs6354 and work stress on burnout (F = 5.08, df = 2, 369, p = 0.007). In the low stress group, G allele carriers had significantly higher burnout level than TT homozygote (F = 11.60, df = 1, 48, p < 0.001). On the contrary, in the high stress group, G allele carriers exhibited significantly lower burnout level compared to TT homozygote (F = 3.86, df = 1, 103, p = 0.025).Conclusions Our findings suggest that the 5-HTT rs6354 polymorphism may modulate the influence of job-related stress on burnout by adjusting serotonin transporter function and neurotransmission, showing that individuals with TT genotype displayed a greater susceptibility to both the detrimental effects of higher stress and the beneficial effects of lower stress compared to those with G allele, which supports the differential-susceptibility hypothesis.