Estrogen treatment of immature rats inhibits ovarian androgen production in vitro.
Estrogen treatment of immature rats inhibits ovarian androgen production in vitro.
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DOI：
10.1210/endo-104-5-1411
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发表时间：
1979-05
期刊：
影响因子：
4.8
通讯作者：
P. Leung;D. Armstrong
中科院分区：
文献类型：
--
作者：
P. Leung;D. Armstrong
本文研究了雌激素对去垂体未成熟雌性大鼠卵巢促黄体生成素和二丁酰环磷酸腺苷的影响。用17β-雌二醇(E_2，1 mg)处理正常大鼠3天，可抑制卵巢对黄体生成素的反应，产生睾酮，但不产生孕酮。在去垂体的动物中，黄体生成素诱导的睾酮和孕酮水平均被E_2减弱。在雌二醇组大鼠(包括正常大鼠和去垂体大鼠)的卵巢孵育液中加入二丁酰cAMP，可显著刺激孕酮的产生，但不能引起任何明显的睾酮的产生。雌二醇组大鼠卵巢缺乏将外源性孕酮转化为睾酮的能力。在用雌二醇处理的正常大鼠中，与来自相似卵泡的大鼠相比，最大卵泡的膜细胞对黄体生成素的反应显著积累了更多的孕酮.
The effects of estrogen treatment of intact vs. hypophysectomized immature female rats on the subsequent in vitro steroidogenic responses of the ovary to LH and dibutyryl cAMP were studied. Treatment of intact rats with 17β-estradiol (E2; 1 mg) for 3 days inhibited the ability of the ovaries to respond to LH with the production of testosterone but not progesterone, whereas both LH-induced testosterone and progesterone levels were attenuated by E2 in hypophysectomized animals. Addition of dibutyryl cAMP to the incubation media of ovaries from the E2-treated rats (both intact and hypophysectomized) markedly stimulated progesterone production but failed to elicit any significant production of testosterone. Ovaries from E2-treated hypophysectomized rats were deficient in converting exogenous progesterone to testosterone. In the E2- treated intact rats, the thecal cells of the largest follicles accumulated significantly greater quantities of progesterone in response to LH when compared to those from similarly ...