Trafficking of TRP channels: determinants of channel function.
Trafficking of TRP channels: determinants of channel function.
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DOI：
10.1007/978-3-540-34891-7_32
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发表时间：
2007
影响因子：
--
通讯作者：
I. Ambudkar
中科院分区：
文献类型：
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作者：
I. Ambudkar
瞬时受体电位（TRP）通道是一个相对较新描述的阳离子通道家族的成员，其显示出广泛的特性和激活机制。大多数这些通道的确切生理功能和调节尚未最终确定。过去十年的研究揭示了有助于其功能的通道的重要特征。这些包括TRP单体之间的同聚相互作用，相同亚家族成员内的选择性异聚相互作用，TRP与辅助蛋白的相互作用和组装成大分子信号传导复合物，以及功能不同的细胞微结构域内的调节。此外，独特的组成和调节囊泡运输机制不仅在控制TRP通道的表面表达，而且在响应刺激时其活化中具有关键作用。许多细胞组分如细胞骨架和支架蛋白也有助于TRP通道运输。因此，参与TRP通道组装和运输的机制控制其质膜表达并对其功能和调节产生重要影响。
Transient receptor potential (TRP) channels are members of a relatively newly described family of cation channels that display a wide range of properties and mechanisms of activation. The exact physiological function and regulation of most of these channels have not yet been conclusively determined. Studies over the past decade have revealed important features of the channels that contribute to their function. These include homomeric interactions between TRP monomers, selective heteromeric interactions within members of the same subfamily, interactions of TRPs with accessory proteins and assembly into macromolecular signaling complexes, and regulation within functionally distinct cellular microdomains. Further, distinct constitutive and regulated vesicular trafficking mechanisms have a critical role not only in controlling the surface expression of TRP channels but also their activation in response to stimuli. A number of cellular components such as cytoskeletal and scaffolding proteins also contribute to TRP channel trafficking. Thus, mechanisms involved in the assembly and trafficking of TRP channels control their plasma membrane expression and critically impact their function and regulation.