HLA antigens in four Pacific populations with non-insulin-dependent diabetes mellitus.
HLA antigens in four Pacific populations with non-insulin-dependent diabetes mellitus.
复制标题
四个太平洋非胰岛素依赖型糖尿病人群的 HLA 抗原。
DOI：
10.1080/03014468200005501
复制
发表时间：
1982
影响因子：
1.7
通讯作者：
LeGonidec,G
中科院分区：
文献类型：
--
作者：
Serjeantson,SW;Ryan,DP;Zimmet,P;Taylor,R;Cross,R;Charpin,M;LeGonidec,G
比较了四个太平洋地区人群中正常和异常糖耐量者的HLA抗原分布。人口包括来自斐济群岛、洛亚蒂群岛和新喀里多尼亚大陆的美拉尼西亚人和来自沃利斯群岛的波利尼西亚人。HLA-DR结果首次为太平洋人群提供。在波利尼西亚人中，HLA-B22在非胰岛素依赖型糖尿病患者和糖耐量受损患者中的频率增加。然而，当校正检测的抗原数量时，这种关联没有统计学意义。在三个糖耐量异常的美拉尼西亚人群中，HLA-B22也有类似的增加，尽管不显著。在血糖浓度异常的人群中，任何HLA抗原均未出现其他一致性增加。
HLA antigen distributions in persons with normal and abnormal glucose tolerance were compared in four Pacific populations. The populations included Melanesians from the Fijian Islands, Loyalty Islands and mainland New Caledonia and Polynesians from the Wallis Islands. HLA-DR results are provided for the first time for Pacific groups. In Polynesians, HLA-B22 was increased in frequency in patients with non-insulin-dependent diabetes mellitus and also in persons with impaired glucose tolerance. However, the association was not statistically significant when corrected for the number of antigens tested. A similar increase in HLA-B22, although not significant, was seen in each of the three Melanesian populations with abnormal glucose tolerance. No other consistent increase in any HLA antigen occurred in persons with abnormal plasma glucose concentrations.