NITRIC-OXIDE - A PATHOGENETIC FACTOR IN AUTOIMMUNITY
NITRIC-OXIDE - A PATHOGENETIC FACTOR IN AUTOIMMUNITY
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DOI：
10.1016/0167-5699(92)90118-q
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发表时间：
1992-05-01
期刊：
影响因子：
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通讯作者：
KOLBBACHOFEN, V
中科院分区：
文献类型：
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作者：
KOLB, H;KOLBBACHOFEN, V
一氧化氮（NO）是一种多功能的介质，由身体的大多数细胞产生并作用于身体的大多数细胞。除了作为内皮源性舒张因子、神经递质和免疫防御分子的功能外，越来越多的证据表明NO参与炎症和自身免疫介导的组织破坏。NO合成和作用的调节代表了治疗炎症和自身免疫性疾病的新方法。
Nitric oxide (NO) has been identified recently as a multifunctional mediator, produced by, and acting on, most cells of the body. Besides its function as endothelium-derived relaxing factor, as a neurotransmitter and as an immune defence molecule, evidence is accumulating that NO participates in inflammatory- and autoimmune-mediated tissue destruction. Modulation of NO synthesis and action represents a new approach to the treatment of inflammatory and autoimmune conditions.