The Analysis of Theophylline — Containing Pharmaceuticals by Room Temperature Phosphorescence
The Analysis of Theophylline — Containing Pharmaceuticals by Room Temperature Phosphorescence
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室温磷光法分析含茶碱药物
DOI：
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发表时间：
1982
期刊：
影响因子：
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通讯作者：
J. Winefordner
中科院分区：
文献类型：
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作者：
R. Bateh;J. Winefordner
摘要：本文采用一种简单、特异的技术分析了茶碱及其相关化合物的药物制剂（胶囊、酏剂、糖浆和片剂）。该方法包括将适量的制剂和标准品溶解（稀释）于1 M ki水溶液中，每种溶液取5 μL滴于滤纸圆盘上，在室温下测定磷光强度并将样品信号电平与标准品的信号电平进行比较。测定中使用的有效成分量和标准从25 ng到1 μg不等。结果表明，室温磷光对分析活性成分通常包含在各种基质中的药物制剂是有用的。
Abstract A simple and specific technique is used in analyzing pharmaceutical preparations (capsules, elixirs, syrups, and tablets) for theophylline and related compounds. The procedure consists of dissolving (diluting) appropriate amounts of the preparations and standards in (with) a 1 M KI-water solution, spotting 5 μL of each resultant solution onto filter paper discs, determining the phosphorescence intensities at room temperature and comparing sample signal levels to those of standards. The quantities of active ingredients and standards used in the determinations ranged from 25 ng to 1 μg. The results indicate that room temperature phosphorescence is useful for analyzing pharmaceutical preparations where active ingredients are usually contained in a wide variety of matrices.