Spatial distribution and relationship of T1rho and T2 relaxation times in knee cartilage with osteoarthritis.
Spatial distribution and relationship of T1rho and T2 relaxation times in knee cartilage with osteoarthritis.
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DOI：
10.1002/mrm.21877
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发表时间：
2009-06
影响因子：
3.3
通讯作者：
Majumdar, Sharmila
中科院分区：
文献类型：
--
作者：
Li, Xiaojuan;Pai, Alex;Blumenkrantz, Gabrielle;Carballido-Gamio, Julio;Link, Thomas;Ma, Benjamin;Ries, Michael;Majumdar, Sharmila
T1ρ和T2弛豫时间常数已被提出来探测骨关节炎软骨中的生化变化。本研究旨在评估骨关节炎软骨中T1ρ和T2值的空间相关性和分布。10例骨关节炎（OA）患者和10名对照者在3 T下进行了研究。使用Z分数研究T1ρ和T2值的空间相关性。本文研究了髌骨软骨不同软骨层的T1ρ和T2值的空间变化。这些弛豫时间常数的分布测量使用纹理分析参数的灰度共生矩阵（GLCM）的基础上。OA患者的T1ρ和T2值的平均Z评分显著高于对照组（P < 0.05）。T1ρ和T2 Z评分的区域相关系数在对照组和OA患者中均显示较大范围（0.2- 0.7）。OA患者的GLCM对比度和T1ρ值的熵值显著高于对照组（P < 0.05）。总之，骨关节炎软骨中的T1ρ和T2值不仅增加，而且也更加不均匀。T1ρ和T2值显示不同的空间分布，并可提供有关OA中软骨退变的补充信息。
T1ρ and T2 relaxation time constants have been proposed to probe biochemical changes in osteoarthritic cartilage. This study aimed to evaluate the spatial correlation and distribution of T1ρ and T2 values in osteoarthritic cartilage. Ten patients with osteoarthritis (OA) and 10 controls were studied at 3T. The spatial correlation of T1ρ and T2 values was investigated using Z-scores. The spatial variation of T1ρ and T2 values in patellar cartilage was studied in different cartilage layers. The distribution of these relaxation time constants was measured using texture analysis parameters based on gray-level co-occurrence matrices (GLCM). The mean Z-scores for T1ρ and T2 values were significantly higher in OA patients vs. controls (P < 0.05). Regional correlation coefficients of T1ρ and T2 Z-scores showed a large range in both controls and OA patients (0.2– 0.7). OA patients had significantly greater GLCM contrast and entropy of T1ρ values than controls (P < 0.05). In summary, T1ρ and T2 values are not only increased but are also more heterogeneous in osteoarthritic cartilage. T1ρ and T2 values show different spatial distributions and may provide complementary information regarding cartilage degeneration in OA.
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影响因子：
3.3
作者：
Foltz, WD;Stainsby, JA;Wright, GA
通讯作者：
Wright, GA
影响因子：
10.9
作者：
Carballido-Gamio, Julio;Bauer, Jan S.;Majumdar, Sharmila
通讯作者：
Majumdar, Sharmila
影响因子：
19.7
作者：
Mosher, TJ;Dardzinski, BJ;Smith, MB
通讯作者：
Smith, MB
影响因子：
3.3
作者：
BRITTAIN, JH;HU, BS;NISHIMURA, DG
通讯作者：
NISHIMURA, DG
影响因子：
1.4
作者：
Gray, M L;Burstein, D;Xia, Y
通讯作者：
Xia, Y