Tertiary lymphoid structures as unique constructions associated with the organization, education, and function of tumor-infiltrating immunocytes
Tertiary lymphoid structures as unique constructions associated with the organization, education, and function of tumor-infiltrating immunocytes
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三级淋巴结构是与肿瘤浸润免疫细胞的组织、教育和功能相关的独特结构
DOI：
10.1631/jzus.b2200174
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发表时间：
2022-10
期刊：
影响因子：
--
通讯作者：
lie wang
中科院分区：
文献类型：
--
作者：
Jing Chen;Jian Chen;lie wang
Tertiary lymphoid structures (TLSs) are formations at sites with persistent inflammatory stimulation, including tumors. These ectopic lymphoid organs mainly consist of chemo-attracting B cells, T cells, and supporting dendritic cells (DCs). Mature TLSs exhibit functional organization for the optimal development and collaboration of adaptive immune response, delivering an augmented effect on the tumor microenvironment (TME). The description of the positive correlation between TLSs and tumor prognosis is reliable only under a certain condition involving the localization and maturation of TLSs. Emerging evidence suggests that underlying mechanisms of the anti-tumor effect of TLSs pave the way for novel immunotherapies. Several approaches have been developed to take advantage of intratumoral TLSs, either by combining it with therapeutic agents or by inducing the neogenesis of TLSs.
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影响因子：
32.4
作者：
Dejardin, E;Droin, NM;Green, DR
通讯作者：
Green, DR
DOI：
10.1056/nejmoa1003466
发表时间：
2010-08-19
期刊：
The New England journal of medicine
影响因子：
--
作者：
Hodi FS;O'Day SJ;McDermott DF;Weber RW;Sosman JA;Haanen JB;Gonzalez R;Robert C;Schadendorf D;Hassel JC;Akerley W;van den Eertwegh AJ;Lutzky J;Lorigan P;Vaubel JM;Linette GP;Hogg D;Ottensmeier CH;Lebbé C;Peschel C;Quirt I;Clark JI;Wolchok JD;Weber JS;Tian J;Yellin MJ;Nichol GM;Hoos A;Urba WJ
通讯作者：
Urba WJ
PD-1( )CXCR5(-)CD4( ) Th-CXCL13细胞亚群驱动B细胞进入鼻咽癌三级淋巴结构
影响因子：
10.9
作者：
Li JP;Wu CY;Chen MY;Liu SX;Yan SM;Kang YF;Sun C;Grandis JR;Zeng MS;Zhong Q
通讯作者：
Zhong Q
影响因子：
4.6
作者：
Song IH;Heo SH;Bang WS;Park HS;Park IA;Kim YA;Park SY;Roh J;Gong G;Lee HJ
通讯作者：
Lee HJ
CXCL13 CD8 T 细胞富集的胃癌患者的临床结果不佳和免疫逃避环境
影响因子：
7.2
作者：
Jin K;Cao Y;Gu Y;Fang H;Fei Y;Wang J;Liu X;Lv K;He X;Lin C;Liu H;Li H;He H;Li R;Zhang H;Xu J
通讯作者：
Xu J