1H MR spectroscopic imaging with short and long echo time to discriminate glycine in glial tumours
1H MR spectroscopic imaging with short and long echo time to discriminate glycine in glial tumours
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DOI：
10.1007/s10334-008-0145-z
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发表时间：
2009-02-01
影响因子：
2.3
通讯作者：
Pilatus, Ulrich
中科院分区：
文献类型：
--
作者：
Hattingen, Elke;Lanfermann, Heinrich;Pilatus, Ulrich
目的：利用H-1磁共振波谱成像（MRSI），在短回波时间（TE）和长回波时间（TE）条件下，研究低级别和高级别胶质瘤中甘氨酸（Gly）的浓度。肌醇（MI）和甘氨酸出现在相同的共振频率为3.56 ppm，但由于强耦合的MI信号更迅速地去相位。因此，它们对3.56 ppm信号的贡献应该是可区分的，比较MRSI数据在短期和长期TE。H-1 MRSI（TE = 30和144 ms）进行了在3 T的29例患者与组织病理学证实的世界卫生组织（WHO）的II-IV级胶质瘤和5名健康受试者。胶质瘤的所有光谱显示在短TE光谱中3.56ppm共振增加。Gly和MI的信号强度通过分析共振的短TE与长TE之比或通过执行加权差来区分。Gly浓度在高级别（WHO III-IV）和低级别胶质瘤之间进行了比较。高级别胶质瘤显示出明显高于低级别胶质瘤的Gly浓度。适当的数据处理的短期和长期TE H-1 MRSI提供了一种工具，以区分和量化Gly和MI浓度的胶质瘤。由于Gly似乎是恶性肿瘤的标志物，因此更专用的光谱方法来区分这些代谢物是合理的。
To investigate glycine (Gly) concentrations in low- and high-grade gliomas based on H-1 MR spectroscopic imaging (MRSI) with short and long echo time (TE). Myoinositol (MI) and Gly appear at the same resonance frequency of 3.56 ppm, but due to strong coupling the MI signal dephases more rapidly. Therefore, their contribution to the 3.56 ppm signal should be distinguishable comparing MRSI data acquired at short and long TE.H-1 MRSI (TE = 30 and 144 ms) was performed at 3 T in 29 patients with histopathological confirmed World Health Organization (WHO) grade II-IV gliomas and in FIVE healthy subjects. All spectra from the gliomas revealed increase of the 3.56 ppm resonance in the short TE spectra. Signal intensities of Gly and MI were differentiated either by analysing the short to long TE ratio of the resonance or by performing a weighted difference. Gly concentrations were compared between high-grade (WHO III-IV) and low-grade gliomas.High-grade gliomas showed significantly higher Gly concentrations compared to low-grade gliomas.Appropriate data processing of short and long TE H-1 MRSI provides a tool to distinguish and to quantify Gly and MI concentrations in gliomas. As Gly seems to be a marker of malignancy, more dedicated spectroscopic methods to differentiate these metabolites are justified.