Joint effects of objectively-measured sedentary time and physical activity on all-cause mortality
Joint effects of objectively-measured sedentary time and physical activity on all-cause mortality
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DOI：
10.1016/j.ypmed.2016.06.026
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发表时间：
2016-09-01
影响因子：
5.1
通讯作者：
Blaha, Michael J.
中科院分区：
文献类型：
--
作者：
Loprinzi, Paul D.;Loenneke, Jeremy P.;Blaha, Michael J.
目标。考察客观测量的久坐时间和中高强度体育活动（MVPA）对全因死亡率的联合影响。本研究包括2003-2006年国家健康与营养调查的数据，以及2011年的死亡率随访数据（通过国家死亡指数）（N = 5575名美国成年人）。使用ActiGraph 7164加速度计客观测量久坐时间（活动计数/分钟0 ~ 99之间）和MVPA（活动计数/分钟= 2020）。参与者的年龄中位数为50岁；男性占50.2%；白人占53.8%，黑人占18.7%；中位随访81个月；在随访期间有511人死亡。在调整了年龄、性别、种族、可替宁、体重状况、贫困水平、c反应蛋白和合共疾病（0-8慢性病总评分），以及MVPA和久坐时间增加1分钟后，MVPA （HRadjusted = 0.98; 95% CI: 0.96-0.99； P= 0.04）和久坐时间（HRadjusted = 1.001; 95% CI: 1.0003-1.002； P= 0.008）与全因死亡率独立相关。此外，MVPA与久坐时间较长的（高于中位数）患者的全因死亡率相关（经hrp调整= 0.95;95% CI: 0.93-0.97; P < 0.001）。久坐时间与MVPA中位水平以上患者的全因死亡率无关（经HR调整= 0.998;95% CI: 0.996-1.001; P = 0.32），但久坐时间与MVPA中位水平以下患者的死亡风险增加相关（HR = 1.002; 95% CI: 1.001-1.003; P < 0.001）。久坐时间和MVPA与全因死亡率独立相关。高于中位久坐时间水平并没有否定MVPA对全因死亡风险的有益作用。(C) 2016 Elsevier Inc.版权所有。
Objective. Examine the joint effects of objectively-measured sedentary time and moderate-to-vigorous physical activity (MVPA) on all-cause mortality.Methods. The present study included data from the 2003-2006 National Health & Nutrition Examination Survey, with mortality follow-up data (via National Death Index) through 2011 (N = 5575 U.S. adults). Sedentary time (activity counts/min between 0 and 99) and MVPA (activity counts/min = 2020) were objectively measured using the ActiGraph 7164 accelerometer.Results. The median age of the participants was 50 yrs; proportion of men was 50.2%; proportion of whites was 53.8%, 18.7% for blacks; median follow-up was 81 months; and 511 deaths occurred over the follow-up period. After adjusting for age, gender, race-ethnicity, cotinine, weight status, poverty level, C-reactive protein and comorbid illness (summed score of 0-8 chronic diseases), and for a 1 min increase in MVPA and sedentary time, both MVPA (HRadjusted = 0.98; 95% CI: 0.96-0.99; P = 0.04) and sedentary time (HRadjusted = 1.001; 95% CI: 1.0003-1.002; P= 0.008)were independently associated with all-cause mortality. Further, MVPA was associated with all-cause mortality among those with greater (above median) sedentary time (HRadjusted = 0.95; 95% CI: 0.93-0.97; P < .001). Sedentary time was not associated with all-cause mortality among those engaging in above median levels of MVPA (HRadjusted = 0.998; 95% CI: 0.996-1.001; P = .32), but sedentary time was associated with increased mortality risk among those below median levels of MVPA (HR = 1.002; 95% CI: 1.001-1.003; P < 0.001).Conclusions. Sedentary time and MVPA are independently associated with all-cause mortality. Above median sedentary time levels did not negate the beneficial effects of MVPA on all-cause mortality risk. (C) 2016 Elsevier Inc. All rights reserved.